Co-reporter: Ben Bradshaw, Claudio Parra, and Josep Bonjoch
pp: 2458-2461
Publication Date(Web):April 29, 2013
DOI: 10.1021/ol400926p
A general effective organocatalyzed synthesis of enantioenriched morphans with up to 92% ee was developed. The morphan scaffold was constructed in a one-pot tandem asymmetric organocatalyzed Michael addition followed by a domino Robinson annulation/aza-Michael intramolecular reaction sequence from easily available starting materials.
