(3-methoxyphenyl)(2-methylphenyl)methanone

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CAS: 57800-65-4
MF: C15H14O2
MW: 226.27046
Synonyms: (3-methoxyphenyl)(2-methylphenyl)methanone

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Zhan Lu

Zhejiang University
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Guohua Hou

Beijing Normal University
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Guofu Zi

Beijing Normal University
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Lin Pu

University of Virginia
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Co-reporter: Li-Hong Zhou, Xiao-Qi Yu, Lin Pu
pp: 475-477
Publication Date(Web):20 January 2010
DOI: 10.1016/j.tetlet.2009.11.079
Aerobic oxidation of a number of diaryl and arylalkyl carbinols to ketones was promoted by Na in THF at room temperature with up to 99% yield. This new oxidation method is also selective with good efficiency for the oxidation of benzylic secondary alcohols but not for a primary alcohol or nonbenzylic secondary alcohols. Under nitrogen, a catalytic amount of Ni or transition metal halides such as CoCl3, FeCl3, and NiCl3 in combination with Na was also found to conduct a dehydrogenation of a secondary alcohol to the corresponding ketone in high yield at room temperature.Image for unlabelled figure