Co-reporter:Peng-Fei Wang, Yi-Si Feng, Zhi-Fei Cheng, Qiu-Min Wu, Guang-Yu Wang, Liang-Liang Liu, Jian-Jun Dai, Jun Xu, and Hua-Jian Xu
The Journal of Organic Chemistry 2015 Volume 80(Issue 18) pp:9314-9320
Publication Date(Web):August 24, 2015
DOI:10.1021/acs.joc.5b01387
A transition-metal-free synthetic method of various ynones via decarboxylative alkynylation of α-keto acids is described. The reaction is carried out under mild conditions and exhibits remarkable tolerance of functional groups. The mechanism of a radical process is proposed in the reaction.
Co-reporter:Peng-Fei Wang, Xiao-Qing Wang, Jian-Jun Dai, Yi-Si Feng, and Hua-Jian Xu
Organic Letters 2014 Volume 16(Issue 17) pp:4586-4589
Publication Date(Web):August 25, 2014
DOI:10.1021/ol502144c
A silver-mediated decarboxylative C–S cross-coupling reaction of aliphatic carboxylic acid is described. This reaction occurs smoothly under mild conditions and shows good tolerance of functional groups. It provides an alternative approach for the synthesis of alkyl aryl sulfides.
Co-reporter:Hua-Jian Xu, Fa-Yin Zheng, Yu-Feng Liang, Zhen-Ya Cai, Yi-Si Feng, Da-Qing Che
Tetrahedron Letters 2010 Volume 51(Issue 4) pp:669-671
Publication Date(Web):27 January 2010
DOI:10.1016/j.tetlet.2009.11.104
CuCl-catalyzed N-arylation of alkyl amines and N-heterocycles with substituted aryl iodides and bromides can be carried out in 40% nBu4N+OH− aqueous solution without any ligands.