Jinxing Ye

Name: 叶金星; Ye, JinXing

Organization: East China University of Science and Technology , China

Department: School of Pharmacy

Title: Professor(PhD)

Chemicals
References

Visible-light photoredox catalyzed hydroacylation of electron-deficient alkenes: carboxylic anhydride as an acyl radical source

Co-reporter:Shupeng Dong;Guibing Wu;Xiaoqian Yuan;Chuncheng Zou

Organic Chemistry Frontiers 2017 vol. 4(Issue 11) pp:2230-2234

Publication Date(Web):2017/10/24

DOI:10.1039/C7QO00453B

A convenient method mediated by photoredox catalysis for the direct construction of 1,4-dicarbonyl compounds has been developed. Simple aromatic symmetric carboxylic anhydrides or mixed anhydrides (generated in situ) have been utilized as an acyl radical source in addition to different types of Michael acceptors. A wide range of substrates are amenable to this new type of acyl Michael addition under mild conditions with broad functional group tolerance. As an application, a novel four-step synthesis of medicinal agent haloperidol is also presented.

Brønsted acid cocatalysis in photocatalytic intramolecular coupling of tertiary amines: efficient synthesis of 2-arylindols

Co-reporter:Xiaoqian Yuan, Xinxin Wu, Shupeng Dong, Guibing Wu and Jinxing Ye

Organic & Biomolecular Chemistry 2016 vol. 14(Issue 31) pp:7447-7450

Publication Date(Web):11 Jul 2016

DOI:10.1039/C6OB01239F

We report herein a highly efficient intramolecular coupling reaction of tertiary amines and ketones (α,β-unsaturated ketones) by using a Brønsted acid as a cocatalyst, affording 2-arylindols in good to excellent yields (up to 92%) under visible light irradiation at room temperature.

Catalytic Asymmetric Formal Aza-Diels–Alder Reactions of α,β-Unsaturated Ketones and 3H-Indoles

Co-reporter:Haoxiang Hu, Chunna Meng, Yun Dong, Xin Li, and Jinxing Ye

ACS Catalysis 2015 Volume 5(Issue 6) pp:3700

Publication Date(Web):May 13, 2015

DOI:10.1021/acscatal.5b00680

Asymmetric formal aza-Diels–Alder reactions with α,β-unsaturated ketones and 3H-indoles with disubstituted groups on the C3 position catalyzed by primary amine-thiourea bifunctional catalyst have been developed. The reactions produced chiral hexahydropyrido-[1,2-a]-indole-2-ones in high yields with excellent diastereo- and enantioselectivities.Keywords: amine; asymmetric catalysis; aza-Diels−Alder; bifunctional catalyst; cycloaddition; piperidinone

Diastereodivergent Catalytic Asymmetric Michael Addition of 2-Oxindoles to α,β-Unsaturated Ketones by Chiral Diamine Catalysts

Co-reporter:Yuan Wei, Shigang Wen, Zunwu Liu, Xinxin Wu, Bubing Zeng, and Jinxing Ye

Organic Letters 2015 Volume 17(Issue 11) pp:2732-2735

Publication Date(Web):May 14, 2015

DOI:10.1021/acs.orglett.5b01149

A diastereodivergent catalytic asymmetric Michael addition of 2-oxindoles to α,β-unsaturated ketones has been successfully developed with two complementary chiral diamine catalysts, affording chiral 3,3-disubstituted oxindoles with two adjacent chiral centers. Diastereodivergence has been realized through modifying substrates and utilizing different catalysts. Either anti-or syn-configured products possessing vicinal quaternary and tertiary stereogenic centers were produced with high enantioselectivities.

Organocatalytic Enantioselective Formal [4 + 2] Cycloaddition of Enones with Cyclic N-Sulfonylimines and Methylene Chromene for Chiral Spirocyclic Compounds

Co-reporter:Jie Fei, Qingqing Qian, Xiaohua Sun, Xiaodong Gu, Chuncheng Zou, and Jinxing Ye

Organic Letters 2015 Volume 17(Issue 21) pp:5296-5299

Publication Date(Web):October 15, 2015

DOI:10.1021/acs.orglett.5b02667

A highly enantioselective synthesis of spirocycles and bridged rings has been developed through a formal [4 + 2] cycloaddition reaction between enones and N-sulfonylimines. The unprecedented strategy has been realized utilizing N-sulfonylimine as a novel dienophile through enamine–iminium tautomerism of N-sulfonylimine. In addition, a γ,ε-regioselective cycloaddition reaction proceeded by employing methylene chromene species as dienophiles.

Copper-Catalyzed Intermolecular Trifluoromethylazidation and Trifluoromethylthiocyanation of Allenes: Efficient Access to CF3-Containing Allyl Azides and Thiocyanates

Co-reporter:Na Zhu, Fei Wang, Pinhong Chen, Jinxing Ye, and Guosheng Liu

Organic Letters 2015 Volume 17(Issue 14) pp:3580-3583

Publication Date(Web):July 9, 2015

DOI:10.1021/acs.orglett.5b01677

A mild and efficient method for copper-catalyzed trifluoromethylazidation and trifluoromethylthiocyanation of allenes was explored. A series of CF3-containing allyl azides and thiocyanates were obtained with high yields and good stereoselectivities, which can be used for further transformation to some valuable compounds.

A General, Scalable, Organocatalytic Nitro-Michael Addition to Enones: Enantioselective Access to All-Carbon Quaternary Stereocenters

Co-reporter:Xiaodong Gu, Yuanyuan Dai, Tingting Guo, Allegra Franchino, Darren J. Dixon, and Jinxing Ye

Organic Letters 2015 Volume 17(Issue 6) pp:1505-1508

Publication Date(Web):March 11, 2015

DOI:10.1021/acs.orglett.5b00387

A tert-leucine-derived chiral diamine catalyzes the asymmetric Michael addition of nitromethane to five-, six-, and seven-membered β-substituted cyclic enones with excellent enantioselectivity, offering scalable, asymmetric access to all-carbon quaternary stereocenters. The reaction scope can be expanded to include linear acyclic enones, and excellent levels of enantioselectivity are also observed. Furthermore, this organocatalytic, asymmetric nitro-Michael reaction is amenable to multigram scale-up and applications in the construction of an eudesmane sesquiterpenoid skeleton.

Transition-metal-free visible-light photoredox catalysis at room-temperature for decarboxylative fluorination of aliphatic carboxylic acids by organic dyes

Co-reporter:Xinxin Wu, Chunna Meng, Xiaoqian Yuan, Xiaotong Jia, Xuhong Qian and Jinxing Ye

Chemical Communications 2015 vol. 51(Issue 59) pp:11864-11867

Publication Date(Web):18 Jun 2015

DOI:10.1039/C5CC04527D

We report herein an efficient, general and green method for decarboxylative fluorination of aliphatic carboxylic acids. By using a transition-metal-free, organocatalytic photoredox system, the reaction of various aliphatic carboxylic acids with the Selectfluor reagent afforded the corresponding alkyl fluorides in satisfactory yields under visible light irradiation at room temperature.

Remote Construction of Chiral Vicinal Tertiary and Quaternary Centers by Catalytic Asymmetric 1,6-Conjugate Addition of Prochiral Carbon Nucleophiles to Cyclic Dienones

Co-reporter:Yuan Wei;Zunwu Liu;Xinxin Wu;Jie Fei;Xiaodong Gu;Xiaoqian Yuan ;Dr. Jinxing Ye

Chemistry - A European Journal 2015 Volume 21( Issue 52) pp:18921-18924

Publication Date(Web):

DOI:10.1002/chem.201503530

Abstract

An unprecedented remote construction of chiral vicinal tertiary and quaternary centers by a catalytic asymmetric 1,6-conjugate addition of prochiral carbon nucleophiles to cyclic dienones has been developed. Both 5H-oxazol-4-ones and 2-oxindoles were found to be very efficient carbon nucleophiles in this reaction at a remote position, giving products with excellent enantio- and diastereoselectivities (up to 99 % ee and >19:1 d.r. for 5H-oxazol-4-ones and up to 97 % ee and >19:1 d.r. for 2-oxindoles).

Acid-catalyzed efficient Friedel–Crafts reaction of indoles with N-Boc aminals

Co-reporter:Kaihe Zou, Jinxing Ye, Xin-Yan Wu

Tetrahedron 2015 Volume 71(Issue 41) pp:7869-7873

Publication Date(Web):14 October 2015

DOI:10.1016/j.tet.2015.08.030

An effective Friedel–Crafts reaction between N-Boc aminals and N-Boc indoles catalyzed by copper(II) trifluoromethanesulfonate has been developed. The less accessible N-Boc imines could be generated in situ from N-Boc aminals. The reaction was achieved in moderate to good yields under mild conditions.

Copper-Catalyzed Trifluoromethylthiolation of Aryl Halides with Diverse Directing Groups

Co-reporter:Jiabin Xu, Xin Mu, Pinhong Chen, Jinxing Ye, and Guosheng Liu

Organic Letters 2014 Volume 16(Issue 15) pp:3942-3945

Publication Date(Web):July 18, 2014

DOI:10.1021/ol501742a

The expansion of cross-coupling components in Cu-catalyzed C–X bond forming reactions have received much attention recently. A novel Cu-catalyzed trifluoromethylthiolation of aryl bromides and iodides with the assistance of versatile directing groups such as pyridyl, methyl ester, amide, imine and oxime was reported. CuBr was used as the catalyst, and 1,10-phenanthroline as the ligand. By changing the solvent from acetonitrile to DMF, the coupling process could even take place at room temperature.

Catalytic Asymmetric Construction of Chiral Hydropyridazines via Conjugate Addition of N-Monosubstituted Hydrazones to Enones

Co-reporter:Wenbin Wu, Xiaoqian Yuan, Juan Hu, Xinxin Wu, Yuan Wei, Zunwu Liu, Junzhu Lu, and Jinxing Ye

Organic Letters 2013 Volume 15(Issue 17) pp:4524-4527

Publication Date(Web):August 21, 2013

DOI:10.1021/ol4020865

The first example of a highly enantioselective and scalable formal diaza–ene reaction between N-monosubstituted hydrazones and enones catalyzed by a simple chiral primary-second diamine salt has been developed. The catalytic process provides a highly practical and stereoselective synthetic method for chiral hydropyridazines.

Aminocatalyzed asymmetric Diels–Alder reaction of 2,4-dienals and rhodanine/hydantoin derivatives

Co-reporter:Kailong Zhu, Huicai Huang, Wenbin Wu, Yuan Wei and Jinxing Ye

Chemical Communications 2013 vol. 49(Issue 21) pp:2157-2159

Publication Date(Web):07 Feb 2013

DOI:10.1039/C3CC00023K

Aminocatalyzed asymmetric Diels–Alder reaction between 2,4-dienals and rhodanine/hydantoin derivatives via trienamine mechanism has been developed to synthesize various spirocyclic compounds with good yields (up to 98%) and excellent stereoselectivities (up to 99% ee and >19:1 dr).

Asymmetric Intramolecular Oxa-Michael Reactions of Cyclohexadienones Catalyzed by a Primary Amine Salt

Co-reporter:Wenbin Wu;Xin Li;Huicai Huang;Xiaoqian Yuan;Junzhu Lu;Kailong Zhu ;Dr. Jinxing Ye

Angewandte Chemie 2013 Volume 125( Issue 6) pp:1787-1791

Publication Date(Web):

DOI:10.1002/ange.201206977

Highly Diastereo- and Enantioselective Cross-Cascade Reactions of Different Enones

Co-reporter:Huicai Huang;Wenbin Wu;Kailong Zhu;Juan Hu ;Dr. Jinxing Ye

Chemistry - A European Journal 2013 Volume 19( Issue 12) pp:3838-3841

Publication Date(Web):

DOI:10.1002/chem.201204520

Asymmetric Intramolecular Oxa-Michael Reactions of Cyclohexadienones Catalyzed by a Primary Amine Salt

Co-reporter:Wenbin Wu;Xin Li;Huicai Huang;Xiaoqian Yuan;Junzhu Lu;Kailong Zhu ;Dr. Jinxing Ye

Angewandte Chemie International Edition 2013 Volume 52( Issue 6) pp:1743-1747

Publication Date(Web):

DOI:10.1002/anie.201206977

Asymmetric construction of spirocyclohexanonerhodanines catalyzed by simple diamine derived from chiral tert-leucine

Co-reporter:Wenbin Wu, Huicai Huang, Xiaoqian Yuan, Kailong Zhu and Jinxing Ye

Chemical Communications 2012 vol. 48(Issue 73) pp:9180-9182

Publication Date(Web):06 Aug 2012

DOI:10.1039/C2CC34321E

A diamine-catalyzed asymmetric tandem reaction between α,β-unsaturated ketones and rhodanine derivatives has been developed to synthesize various spirocyclic compounds with high stereoselectivities (up to 99% ee and >20:1 dr). The products obtained contain two pharmaceutically relevant features: the biologically active rhodanine moiety embedded in a spirocyclic unit.

Asymmetric Michael Addition of Substituted Rhodanines to α,β-Unsaturated Ketones Catalyzed by Bulky Primary Amines

Co-reporter:Feng Yu, Haoxiang Hu, Xiaodong Gu, and Jinxing Ye

Organic Letters 2012 Volume 14(Issue 8) pp:2038-2041

Publication Date(Web):April 6, 2012

DOI:10.1021/ol300489q

A bulky group was introduced by design into a diamine catalyst, and a series of robust and tunable bulky chiral primary amine catalysts were developed and successfully applied in the direct conjugate addition of substituted rhodanines to α,β-unsaturated ketones. High yields (up to 99%) and excellent diastereoselectivities (up to 99:1 dr) and enantioselectivities (up to 98% ee) were observed.

Highly diastereoselective and enantioselective Michael addition of 5H-oxazol-4-ones to α,β-unsaturated ketones catalyzed by a new bifunctional organocatalyst with broad substrate scope and applicability

Co-reporter:Huicai Huang, Kailong Zhu, Wenbin Wu, Zhichao Jin and Jinxing Ye

Chemical Communications 2012 vol. 48(Issue 3) pp:461-463

Publication Date(Web):11 Nov 2011

DOI:10.1039/C1CC15928C

A new thiourea–tertiary amine bifunctional catalyst derived from L-tert-leucine was developed and provides excellent stereocontrol in a novel and direct Michael addition of 5H-oxazol-4-ones to α,β-unsaturated ketones with much broad substrate scope. The conjugate addition products with chiral vicinal quaternary and tertiary stereocenters can be easily transformed to structurally interesting compounds or building blocks.

Highly diastereo- and enantioselective one-pot Michael–Aldol reactions of α,β-unsaturated aldehydes with imidazole derivatives

Co-reporter:Wenjun Li, Xin Li, Wenbin Wu, Xinmiao Liang and Jinxing Ye

Chemical Communications 2011 vol. 47(Issue 29) pp:8325-8327

Publication Date(Web):20 Jun 2011

DOI:10.1039/C1CC12300A

Highly diastereo- and enantioselective one-pot Michael–Aldol reactions of α,β-unsaturated aldehydes with imidazole derivatives have been developed. The cascade reactions products could be obtained with three stereocenters in high yields and excellent diastereo- and enantioselectivities.

Diastereo- and Enantioselective Synthesis of Oxazine and Oxazolidine Derivatives with a Chiral Quaternary Carbon Center under Multifunctional Catalysis

Co-reporter:Zhichao Jin, Xiao Wang, Huicai Huang, Xinmiao Liang, and Jinxing Ye

Organic Letters 2011 Volume 13(Issue 4) pp:564-567

Publication Date(Web):January 14, 2011

DOI:10.1021/ol102643a

An easy one-pot, multistep cascade reaction which could afford a series of substituted benzo[d]pyrido[2,1-b]oxazolidine and [1,3]oxazine derivatives in a highly enantio- (up to 98% ee) and diastereoselective (4:1 to >20:1 dr) manner with generally good to excellent yields (up to 99%) has been developed. This well designed strategy could be applied to a wide scope of substrates under mild conditions with simple operations.

Enantioselective Organocatalytic Synthesis of Oxazolidine Derivatives through a One-Pot Cascade Reaction

Co-reporter:Zhichao Jin;Huicai Huang;Wenjun Li;Xiaoyan Luo;Xinmiao Liang

Advanced Synthesis & Catalysis 2011 Volume 353( Issue 2-3) pp:343-348

Publication Date(Web):

DOI:10.1002/adsc.201000647

Abstract

An asymmetric organocatalytic cascade reaction which can afford a series of oxazolidine derivatives has been developed. The one-pot reaction reported here can produce an oxazolidine derivative in a highly enantioselective manner and good yield with good to excellent diastereomeric ratio.

A one-pot asymmetric organocatalytic tandem reaction for the synthesis of oxazine derivatives

Co-reporter:Zhichao Jin, Feng Yu, Xiao Wang, Huicai Huang, Xiaoyan Luo, Xinmiao Liang and Jinxing Ye

Organic & Biomolecular Chemistry 2011 vol. 9(Issue 6) pp:1809-1816

Publication Date(Web):25 Jan 2011

DOI:10.1039/C0OB00669F

An easy one-pot tandem reaction catalyzed by a chiral secondary amine for the synthesis of optically active oxazine derivatives has been performed and the corresponding substituted benzo[d]pyrido[2,1-b][1,3]oxazine derivatives were afforded in generally high yields (up to 99%) and excellent enantioselectivities (up to >99%).

Catalytic asymmetric Michael addition with curcumin derivative

Co-reporter:Wenjun Li, Wenbin Wu, Feng Yu, Huicai Huang, Xinmiao Liang and Jinxing Ye

Organic & Biomolecular Chemistry 2011 vol. 9(Issue 7) pp:2505-2511

Publication Date(Web):21 Feb 2011

DOI:10.1039/C0OB00757A

Catalytic asymmetric Michael additions with curcumin derivatives were achieved by a new series of tertiary amine–thiourea organocatalysts to afford the Michael adducts in high yields and excellent enantioselectivities.

Catalytic asymmetric Michael addition of α,β-unsaturated aldehydes to Ni(II) complexes of the Schiff base of glycine

Co-reporter:Xiaoyan Luo, Zhichao Jin, Pengfei Li, Jiabin Gao, Weimin Yue, Xinmiao Liang and Jinxing Ye

Organic & Biomolecular Chemistry 2011 vol. 9(Issue 3) pp:793-801

Publication Date(Web):22 Nov 2010

DOI:10.1039/C0OB00221F

The conjugate addition of Ni(II) complexes of glycine Schiff base to α,β-unsaturated aldehydes catalyzed by (S)-2-(diphenyl(trimethylsilyloxy)methyl)pyrrolidine afforded adducts in excellent yields with up to 49:1 dr and 95% ee. This method enables the construction of two adjacent chiral centers in one step, and offers an alternative route to chiral α-amino acid derivatives.

Enantioselective organocatalytic phospha-Michael reaction of α,β-unsaturated aldehydes

Co-reporter:Xiaoyan Luo, Zhiqiang Zhou, Xin Li, Xinmiao Liang and Jinxing Ye

RSC Advances 2011 vol. 1(Issue 4) pp:698-705

Publication Date(Web):25 Aug 2011

DOI:10.1039/C1RA00269D

The enantioselective organocatalytic phospha-Michael reaction of α,β-unsaturated aldehydes with diaryl phosphine oxides is explored for the first time using (S)-2-(diphenyl(trimethylsilyloxy)methyl)pyrrolidine as a catalyst. It afforded 1,4-addition adducts in good to excellent yields with up to 99% ee.

Asymmetric organocatalytic Michael/α-alkylation reaction of α,β-unsaturated aldehyde with chloroacetophenone

Co-reporter:Wenjun Li, Xin Li, Tingting Ye, Wenbin Wu, Xinmiao Liang, Jinxing Ye

Tetrahedron Letters 2011 Volume 52(Issue 21) pp:2715-2718

Publication Date(Web):25 May 2011

DOI:10.1016/j.tetlet.2011.03.079

Asymmetric organocatalytic Michael/α-alkylation reactions of α,β-unsaturated aldehydes with chloroacetophenones have been developed. The biologically useful cyclopropane motifs were synthesized with high yields and up to >99% ee, >30:1 dr through Jørgensen–Hayashi catalyst under mild conditions.

Highly Diastereo- and Enantioselective Synthesis of 5-Substituted 3-Pyrrolidin-2-ones: Vinylogous Michael Addition under Multifunctional Catalysis

Co-reporter:Huicai Huang;Zhichao Jin;Kailong Zhu;Dr. Xinmiao Liang ;Dr. Jinxing Ye

Angewandte Chemie International Edition 2011 Volume 50( Issue 14) pp:3232-3235

Publication Date(Web):

DOI:10.1002/anie.201008255

Highly Diastereo- and Enantioselective Synthesis of 5-Substituted 3-Pyrrolidin-2-ones: Vinylogous Michael Addition under Multifunctional Catalysis

Co-reporter:Huicai Huang;Zhichao Jin;Kailong Zhu;Dr. Xinmiao Liang ;Dr. Jinxing Ye

Angewandte Chemie 2011 Volume 123( Issue 14) pp:3290-3293

Publication Date(Web):

DOI:10.1002/ange.201008255

Catalytic Asymmetric Michael Reactions of ,-Unsaturated Ketones with Sulfonyl-Containing Nucleophiles: Chiral Synthesis of (R)-Muscone and (S)-Celery Ketone

Co-reporter:Xiaomin Sun;Feng Yu;Tingting Ye;Dr. Xinmiao Liang ;Dr. Jinxing Ye

Chemistry - A European Journal 2011 Volume 17( Issue 2) pp:430-434

Publication Date(Web):

DOI:10.1002/chem.201002418

Enantioselective Michael Reaction of α-Alkyl-β-keto Esters and Enones under Multifunctional Catalysis

Co-reporter:Juanjuan Yang, Wenjun Li, Zhichao Jin, Xinmiao Liang, and Jinxing Ye

Organic Letters 2010 Volume 12(Issue 22) pp:5218-5221

Publication Date(Web):October 18, 2010

DOI:10.1021/ol102256v

An efficient approach for the enantioselective Michael additions of β-alkyl-β-keto esters to β-substituted α,β-unsaturated ketones has been developed. The Michael products could be obtained in good to excellent yields (75−98%) with excellent diastereoselectivities (up to >99:1 dr) and enantioselectivities (up to 96% ee) and could easily be transformed into a synthetically useful hexahydrophenanthrene structure under mild conditions in good yield.

Asymmetric vinylogous Michael reaction of α,β-unsaturated ketones with γ-butenolide under multifunctional catalysis

Co-reporter:Huicai Huang, Feng Yu, Zhichao Jin, Wenjun Li, Wenbin Wu, Xinmiao Liang and Jinxing Ye

Chemical Communications 2010 vol. 46(Issue 32) pp:5957-5959

Publication Date(Web):02 Jul 2010

DOI:10.1039/C0CC01054E

A general and direct organocatalytic asymmetric vinylogous Michael reaction of γ-butenolide with α,β-unsaturated ketones was investigated with a multifunctional primary amine salt as catalyst. The reaction enables straightforward access toward synthetically versatile γ-substituted butenolides from simple 2(5H)-furanone with satisfactory yields, diastereo- and enantioselectivities (up to 30:1 dr and 95–99% ee).

Enantioselective organocatalytic phospha-Michael reaction of α,β-unsaturated ketones

Co-reporter:Shigang Wen, Pengfei Li, Haibo Wu, Feng Yu, Xinmiao Liang and Jinxing Ye

Chemical Communications 2010 vol. 46(Issue 26) pp:4806-4808

Publication Date(Web):25 May 2010

DOI:10.1039/C0CC00094A

Enantioselective organocatalytic phospha-Michael reaction of α,β-unsaturated ketones and diaryl phosphine oxides has been developed for the first time employing multifunctional organocatalysts. Optically active products bearing quaternary chiral carbon stereocenters were obtained in high yields with good to excellent enantioselectivities (up to 98% ee).

Enantioselective Michael addition of ketones to maleimides catalyzed by bifunctional monosulfonyl DPEN salt

Co-reporter:Feng Yu, Xiaomin Sun, Zhichao Jin, Shigang Wen, Xinmiao Liang and Jinxing Ye

Chemical Communications 2010 vol. 46(Issue 25) pp:4589-4591

Publication Date(Web):18 May 2010

DOI:10.1039/C0CC00774A

An unprecedented enantioselective Michael addition of various ketones to maleimides catalyzed by a simple bifunctional primary amine, monosulfonyl DPEN salt, is reported and provides the desired adducts in good to excellent yields (up to 99%) with excellent enantioselectivities (up to 99%).

Asymmetric organocatalytic Michael addition of anthrone to enone

Co-reporter:Chunlin Wu, Wenjun Li, Juanjuan Yang, Xinmiao Liang and Jinxing Ye

Organic & Biomolecular Chemistry 2010 vol. 8(Issue 14) pp:3244-3250

Publication Date(Web):21 May 2010

DOI:10.1039/B927421A

Catalyzed by the bifunctional tertiary amino–thiourea organocatalyst derived from epicinchona alkaloid, the asymmetric Michael addition of anthrone to enone was achieved in high yield with excellent enantioselectivity.

A highly efficient asymmetric Michael addition of α,α-disubstituted aldehydes to maleimides catalyzed by primary amine thiourea salt

Co-reporter:Feng Yu, Zhichao Jin, Huicai Huang, Tingting Ye, Xinmiao Liang and Jinxing Ye

Organic & Biomolecular Chemistry 2010 vol. 8(Issue 20) pp:4767-4774

Publication Date(Web):23 Aug 2010

DOI:10.1039/C0OB00154F

The first highly efficient Michael addition of challenging α,α-disubstituted aldehydes to maleimides catalyzed by a simple bifunctional primary amine thiourea catalyst/benzoic acid system has been successfully developed to generate quaternary carbon centers in high yields (up to 99%) with excellent enantioselectivities (91–99%).

An efficient enantioselective method for asymmetric Michael addition of nitroalkanes to α,β-unsaturated aldehydes

Co-reporter:Yongcan Wang, Pengfei Li, Xinmiao Liang, Tony Y. Zhang and Jinxing Ye

Chemical Communications 2008 (Issue 10) pp:1232-1234

Publication Date(Web):31 Jan 2008

DOI:10.1039/B717000A

The addition of nitroalkanes to α,β-unsaturated aldehydes under the catalysis of (S)-2-(diphenyl(trimethylsilyloxy)methyl)pyrrolidine and lithium acetate as additive afforded γ-nitroaldehydes in good yield and up to 97% ee.

Asymmetric multifunctional organocatalytic Michael addition of nitroalkanes to α,β-unsaturated ketones

Co-reporter:Pengfei Li, Yongcan Wang, Xinmiao Liang and Jinxing Ye

Chemical Communications 2008 (Issue 28) pp:3302-3304

Publication Date(Web):16 May 2008

DOI:10.1039/B804540B

Cinchona alkaloid derived primary amine thioureas organocatalyzed Michael addition of nitroalkanes to enones in good yield and up to 98% ee and offered a new way to construct quaternary stereocenters from enones and nitroalkanes.

Asymmetric multifunctional organocatalytic Michael addition of nitroalkanes to α,β-unsaturated ketones

Co-reporter:Pengfei Li, Yongcan Wang, Xinmiao Liang and Jinxing Ye

Chemical Communications 2008(Issue 28) pp:NaN3304-3304

Publication Date(Web):2008/05/16

DOI:10.1039/B804540B

An efficient enantioselective method for asymmetric Michael addition of nitroalkanes to α,β-unsaturated aldehydes

Co-reporter:Yongcan Wang, Pengfei Li, Xinmiao Liang, Tony Y. Zhang and Jinxing Ye

Chemical Communications 2008(Issue 10) pp:NaN1234-1234

Publication Date(Web):2008/01/31

DOI:10.1039/B717000A

Catalytic asymmetric Michael addition with curcumin derivative

Co-reporter:Wenjun Li, Wenbin Wu, Feng Yu, Huicai Huang, Xinmiao Liang and Jinxing Ye

Organic & Biomolecular Chemistry 2011 - vol. 9(Issue 7) pp:NaN2511-2511

Publication Date(Web):2011/02/21

DOI:10.1039/C0OB00757A

A one-pot asymmetric organocatalytic tandem reaction for the synthesis of oxazine derivatives

Co-reporter:Zhichao Jin, Feng Yu, Xiao Wang, Huicai Huang, Xiaoyan Luo, Xinmiao Liang and Jinxing Ye

Organic & Biomolecular Chemistry 2011 - vol. 9(Issue 6) pp:NaN1816-1816

Publication Date(Web):2011/01/25

DOI:10.1039/C0OB00669F

Enantioselective Michael addition of ketones to maleimides catalyzed by bifunctional monosulfonyl DPEN salt

Co-reporter:Feng Yu, Xiaomin Sun, Zhichao Jin, Shigang Wen, Xinmiao Liang and Jinxing Ye

Chemical Communications 2010 - vol. 46(Issue 25) pp:NaN4591-4591

Publication Date(Web):2010/05/18

DOI:10.1039/C0CC00774A

Aminocatalyzed asymmetric Diels–Alder reaction of 2,4-dienals and rhodanine/hydantoin derivatives

Co-reporter:Kailong Zhu, Huicai Huang, Wenbin Wu, Yuan Wei and Jinxing Ye

Chemical Communications 2013 - vol. 49(Issue 21) pp:NaN2159-2159

Publication Date(Web):2013/02/07

DOI:10.1039/C3CC00023K

Co-reporter:Huicai Huang, Kailong Zhu, Wenbin Wu, Zhichao Jin and Jinxing Ye

Chemical Communications 2012 - vol. 48(Issue 3) pp:NaN463-463

Publication Date(Web):2011/11/11

DOI:10.1039/C1CC15928C

Enantioselective organocatalytic phospha-Michael reaction of α,β-unsaturated ketones

Co-reporter:Shigang Wen, Pengfei Li, Haibo Wu, Feng Yu, Xinmiao Liang and Jinxing Ye

Chemical Communications 2010 - vol. 46(Issue 26) pp:NaN4808-4808

Publication Date(Web):2010/05/25

DOI:10.1039/C0CC00094A

Highly diastereo- and enantioselective one-pot Michael–Aldol reactions of α,β-unsaturated aldehydes with imidazole derivatives

Co-reporter:Wenjun Li, Xin Li, Wenbin Wu, Xinmiao Liang and Jinxing Ye

Chemical Communications 2011 - vol. 47(Issue 29) pp:NaN8327-8327

Publication Date(Web):2011/06/20

DOI:10.1039/C1CC12300A

Catalytic asymmetric Michael addition of α,β-unsaturated aldehydes to Ni(II) complexes of the Schiff base of glycine

Co-reporter:Xiaoyan Luo, Zhichao Jin, Pengfei Li, Jiabin Gao, Weimin Yue, Xinmiao Liang and Jinxing Ye

Organic & Biomolecular Chemistry 2011 - vol. 9(Issue 3) pp:NaN801-801

Publication Date(Web):2010/11/22

DOI:10.1039/C0OB00221F

Asymmetric vinylogous Michael reaction of α,β-unsaturated ketones with γ-butenolide under multifunctional catalysis

Co-reporter:Huicai Huang, Feng Yu, Zhichao Jin, Wenjun Li, Wenbin Wu, Xinmiao Liang and Jinxing Ye

Chemical Communications 2010 - vol. 46(Issue 32) pp:NaN5959-5959

Publication Date(Web):2010/07/02

DOI:10.1039/C0CC01054E

A highly efficient asymmetric Michael addition of α,α-disubstituted aldehydes to maleimides catalyzed by primary amine thiourea salt

Co-reporter:Feng Yu, Zhichao Jin, Huicai Huang, Tingting Ye, Xinmiao Liang and Jinxing Ye

Organic & Biomolecular Chemistry 2010 - vol. 8(Issue 20) pp:NaN4774-4774

Publication Date(Web):2010/08/23

DOI:10.1039/C0OB00154F

Transition-metal-free visible-light photoredox catalysis at room-temperature for decarboxylative fluorination of aliphatic carboxylic acids by organic dyes

Co-reporter:Xinxin Wu, Chunna Meng, Xiaoqian Yuan, Xiaotong Jia, Xuhong Qian and Jinxing Ye

Chemical Communications 2015 - vol. 51(Issue 59) pp:NaN11867-11867

Publication Date(Web):2015/06/18

DOI:10.1039/C5CC04527D

Asymmetric organocatalytic Michael addition of anthrone to enone

Co-reporter:Chunlin Wu, Wenjun Li, Juanjuan Yang, Xinmiao Liang and Jinxing Ye

Organic & Biomolecular Chemistry 2010 - vol. 8(Issue 14) pp:NaN3250-3250

Publication Date(Web):2010/05/21

DOI:10.1039/B927421A

Asymmetric construction of spirocyclohexanonerhodanines catalyzed by simple diamine derived from chiral tert-leucine

Co-reporter:Wenbin Wu, Huicai Huang, Xiaoqian Yuan, Kailong Zhu and Jinxing Ye

Chemical Communications 2012 - vol. 48(Issue 73) pp:NaN9182-9182

Publication Date(Web):2012/08/06

DOI:10.1039/C2CC34321E

Brønsted acid cocatalysis in photocatalytic intramolecular coupling of tertiary amines: efficient synthesis of 2-arylindols

Co-reporter:Xiaoqian Yuan, Xinxin Wu, Shupeng Dong, Guibing Wu and Jinxing Ye

Organic & Biomolecular Chemistry 2016 - vol. 14(Issue 31) pp:NaN7450-7450

Publication Date(Web):2016/07/11

DOI:10.1039/C6OB01239F

CAS:882526-19-4

Pyridine, 2-(3-bromophenyl)-4-methyl-

CAS:882526-18-3

PYRIDINE, 2-(3-CHLOROPHENYL)-4-METHYL-

CAS:848649-91-2

2H-Indole-2-thione,5-bromo-1,3-dihydro-

Dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin,4-hydroxy-2,6-bis[2,4,6-tris(1-methylethyl)phenyl]-, 4-oxide, (11bR)-

CAS:791616-63-2

Dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin,4-hydroxy-2,6-bis[2,4,6-tris(1-methylethyl)phenyl]-, 4-oxide, (11bR)-

CAS:699006-54-7

CAS:695162-86-8

4-IMIDAZOLIDINONE, 5-(1-PHENYLETHYLIDENE)-2-THIOXO-, (5Z)-

CAS:503065-72-3

4-IMIDAZOLIDINONE, 5-(1-PHENYLETHYLIDENE)-2-THIOXO-, (5Z)-

2H-Indole-2-thione, 6-chloro-1,3-dihydro-

CAS:392332-34-2

2H-Indole-2-thione, 6-chloro-1,3-dihydro-

4-Thiazolidinone, 5-(phenylmethylene)-2-thioxo-, (5Z)-

CAS:174813-23-1

4-Thiazolidinone, 5-(phenylmethylene)-2-thioxo-, (5Z)-

CAS:138616-38-3

2-Cyclohexen-1-one, 3-(phenylethynyl)-