•A metal–organic frameworks and Ag-CuTCPP MOFs were synthesized and characterized.•The antimicrobial activities and cytotoxicity of Ag-CuTCPP MOFs were performed by in vitro and in vivo.•Ag-CuTCPP MOFs have better antibacterial effect and lower cytotoxicity.A metal–organic frameworks (CuTCPP MOFs) were synthesized with Cu(NO3)2·3H2O and 5,10,15,20-tetrakis(4-carboxyphenyl)porphyrin (TCPP) by the solvothermal method. The structure and morphology of the CuTCPP MOFs were characterized by UV–vis absorption spectra, X-ray diffraction (PXRD), energy dispersive spectra, scanning electron microscopy (EDS-SEM) and transmission electron microscopy (TEM). The structure of the as-synthesized MOF includes copper ions and copper metalloporphyrin (Cu-TCPP) by UV–vis absorption spectra and PXRD. The SEM and TEM images of the as-synthesized MOF showed the morphology of the CuTCPP MOFs were spherical. The as-synthesized spherical MOFs as the carriers were used to encapsulate the Ag nanoparticles and prepared Ag-CuTCPP MOFs. The Ag-CuTCPP MOFs was also characterized by UV–vis, PXRD, SEM and TEM. The Ag nanoparticles were completely encapsulated into the CuTCPP MOFs and no surface absorption, which have been confirmed by comparing TEM and SEM-EDS of Ag-CuTCPP MOFs before crushing with that of Ag-CuTCPP MOFs after crushing. In addition, the release of Ag ions from Ag-CuTCPP MOFs was also investigated by Inductively Coupled Plasma Optical Emission Spectrometer (ICP-OES). Furthermore, the antimicrobial activities and cytotoxicity of Ag-CuTCPP MOFs were performed by in vitro and in vivo experiment. In vitro, the antibacterial effect of Ag-CuTCPP MOFs was even better than that of the penicillin as the positive control and the cytotoxicity of Ag-CuTCPP MOFs was significantly lower than that of naked Ag nanoparticles and Ag ions; in vivo, Ag-CuTCPP MOFs not only exhibited the excellently antibacterial effect and extremely low cytotoxicity but also effectively promoted the wound healing.

Pure copper was processed by equal channel angular pressing (ECAP) using route Bc with a die channel angle of 110°. Electron back scattered diffraction (EBSD) and transmission electron microscopy (TEM) were used to analyze the microstructure and texture during ECAP processing and after combining ECAP with micro-compression. Ultrafine-grained pure copper with an average grain size of ~0.5 µm was achieved after ECAP processing through 12 passes. The anisotropic behavior during micro-compression is caused by the micro-texture of pure copper introduced by ECAP processing. Three kinds of strain softening behaviors are found during micro-compression tests in pure copper processed by ECAP. The strain softening of micro/meso deformation in UFG pure copper is caused by the accelerated dislocations annihilation due to the high dislocation recoveries at HAGBs, which is consistent with the deformation mechanism of grain boundary sliding and grain rotation.

Micro-compression testing was conducted using high purity Al processed by equal-channel angular pressing (ECAP) with both coarse-grained (CG) and ultrafine-grained (UFG) samples. The effects on the flow stresses of the initial grain size and the specimen size were investigated and the results show the initial grain sizes and the specimen dimensions affect the flow stresses during micro-compression for both CG and UFG specimens. There is a transition from strain hardening to strain softening with decreasing grain size during micro-compression but the transition grain size is dependent upon the size of the specimen. These results are interpreted using a model based on the separate influences of dislocation annihilation and dislocation accumulation in the UFG and CG materials, respectively. The results demonstrate that the occurrence of surface roughening is improved when using UFG pure Al and this shows there is a significant potential for using UFG pure Al in micro-forming operations.

Micro-forming technology poses much higher demands on positioning accuracy, velocity and mass production, and the common forming machines cannot satisfy these requirements using traditional drive methods. Micro-forming equipment using novel drive methods with high speed and high precision has become an important research field for industrial application. In the paper, a novel drive mechanism was designed with a symmetric distributed double linear motors and a micro-forming system was developed with micro-punching tools and automatic feeding apparatus for metal foil. The servo control system of this micro-forming system was designed using SIMOTION D445, and a parallel control model was adopted with a single motor module to solve the synchronous control problems of double linear motors. Micro-punching process of brass foil was studied with the micro-forming system, and micro-holes of 600 μm, 300 μm and 150 μm in diameter were manufactured with high dimensional accuracy. An array of 50 × 4 micro-holes, each 600 μm in diameter, was manufactured using an automatic feeding apparatus guided by a microscopic visualization system for assisted localization. The results indicate that the micro-forming system with high-accuracy and high-speed is suitable for the mass production of micro-scale parts.

In this paper, the structural and zeta potential properties of 10-hydroxycamptothecin (HCPT) were investigated by FT-IR and zeta potential analyzer under different pH. The anticancer drug HCPT as a model drug was used to prepare a high-performance and relatively easy-to-fabricate system on Fe3O4 magnetite nanoparticles by using a polystyrene sulfonate (PSS) and HCPT interlayer self-assembly method. The results obtained from FT-IR and XRD confirmed that HCPT was molecularly dispersed into the nanoparticles. The method holds not only environment-friendly characteristics and the ability to mimic the self-organization process in biological systems but also greatly decreases adjuvant polymers. In addition, the system has an ideal drug payload for the delivery of insoluble HCPTs.

In this paper, the novel chiral porphyrin dimer ligand and its cobalt(II) porphyrin dimer were synthesized by using a glutamate bridging group. The FT-IR and Raman spectra of the chiral porphyrin dimer were investigated. Furthermore, the photochemical and electrochemical properties of dimer were studied. In addition, we prepared the nanorods of the cobalt(II) porphyrin dimer using liquid–solid-solution (LSS) technologies. The shape and dimension of the spontaneous aggregates of cobalt(II) porphyrin dimer were characterized by the transmission electron microscopy (TEM). The results show the diameter and shape of the aggregates can be controlled by refining the stocked solution temperature.For aggregate morphologies of cobalt(II) porphyrin dimer, the H-aggregate or nonspecific aggregate is dominant in lower temperature, while the J-aggregate is dominant in higher temperature. The ordered chiral nanorods of cobalt(II) porphyrin dimer were formed when the aggregate morphologies transform from H- to J-aggregate with the temperature of the system increase.

Nanocrystalline/amorphous matrix composites obtained by isothermal compression at high temperatures and low strain rates were characterized using transmission electron microscopy. To study the influence of high temperature deformation on the fracture behavior and room temperature plasticity, compression tests with a constant strain rate of 1 × 10−4 s−1 were applied to the deformed samples. Fracture features of as-cast alloy and deformed samples were analyzed using scanning electron microscopy. Compared with the as-cast alloy, the room temperature plasticity of deformed sample is not destroyed both in the range of 370–395 °C at 1 × 10−3 s−1 and at 395 °C in 1 × 10−2 to 1 × 10−3 s−1, and deteriorated at higher temperatures and lower strain rates. Corresponding to the TEM images, the homogenously dispersed nanocrystals with small size contribute to the compressive plasticity, and the aggregated large nanoparticles destroy the plasticity of the sample after high temperature deformation.

In this paper, the structural and zeta potential properties of 10-hydroxycamptothecin (HCPT) were investigated by FT-IR and zeta potential analyzer under different pH. The anticancer drug HCPT as a model drug was used to prepare a high-performance and relatively easy-to-fabricate system on Fe3O4 magnetite nanoparticles by using a polystyrene sulfonate (PSS) and HCPT interlayer self-assembly method. The results obtained from FT-IR and XRD confirmed that HCPT was molecularly dispersed into the nanoparticles. The method holds not only environment-friendly characteristics and the ability to mimic the self-organization process in biological systems but also greatly decreases adjuvant polymers. In addition, the system has an ideal drug payload for the delivery of insoluble HCPTs.