Hai-ming Guo *?

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Organization: Henan Normal University

Department: College of Chemistry and Environmental Science

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Chemicals
References

Organocatalytic enantioselective Michael addition of malononitrile to nitroolefins catalyzed by bifunctional thiourea

Co-reporter:Hai-Ming Guo;Jian-Guo Li;Gui-Rong Qu;Xiao-Mei Zhang;Wei-Cheng Yuan

Chirality 2011 Volume 23( Issue 7) pp:514-518

Publication Date(Web):

DOI:10.1002/chir.20956

Abstract

A novel enantioselective Michael addition of malononitrile to trans-β-nitroolefins in the presence of bifunctional amine thiourea organocatalyst is developed. The Michael reaction catalyzed by amine thioureas containing both central and axial chiral elements proceeded smoothly and provided the desired adducts with high yields (up to 96% yield) and moderate enantioselectivities (up to 83% enantiomeric excess). Chirality, 2011. © 2011 Wiley-Liss, Inc.

Straightforward and Highly Efficient Catalyst-Free One-Step Synthesis of 2-(Purin-6-yl)acetoacetic Acid Ethyl Esters, (Purin-6-yl)acetates, and 6-Methylpurines through SNAr-Based Reactions of 6-Halopurines with Ethyl Acetoacetate

Co-reporter:Gui-Rong Qu, Zhi-Jie Mao, Hong-Ying Niu, Dong-Chao Wang, Chao Xia, and Hai-Ming Guo

Organic Letters 2009 Volume 11(Issue 8) pp:1745-1748

Publication Date(Web):March 18, 2009

DOI:10.1021/ol9002256

A novel approach to the synthesis of purines bearing functionalized carbon substituents or methyl in position 6 was developed. Under different reaction conditions, 6-halopurine derivatives could react with ethyl acetoacetate efficiently to yield 2-(purin-6-yl)acetoacetic acid ethyl esters, (purin-6-yl)acetates and 6-methylpurines respectively. No metal catalyst and ligand were required.