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Kai Guo

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Organization: Nanjing Tech University
Department: College of Biotechnology and Pharmaceutical Engineering
Title:
Phytic acid: a biogenic organocatalyst for one-pot Biginelli reactions to 3,4-dihydropyrimidin-2(1H)-ones/thiones
Co-reporter:Qiguo Zhang, Xin Wang, Zhenjiang Li, Wenzhuo Wu, Jingjing Liu, Hao Wu, Saide Cui and Kai Guo  
RSC Advances 2014 vol. 4(Issue 38) pp:19710-19715
Publication Date(Web):08 Apr 2014
DOI:10.1039/C4RA02084G
The natural organocatalyst phytic acid catalyzed one-pot Biginelli reactions by coupling β-ketoesters, aldehydes, and (thio)ureas to afford 3,4-dihydropyrimidin-2(1H)-ones/thiones. This phytic acid catalysis featured good to excellent isolated yields, solvent-free conditions, a simple workup, environmental friendliness, and a short reaction time.
Efficient synthesis of chromenopyridine and chromene via MCRs
Co-reporter:Hai-Feng Gan, Wei-Wei Cao, Zheng Fang, Xin Li, Shi-Gui Tang, Kai Guo
Chinese Chemical Letters 2014 Volume 25(Issue 10) pp:1357-1362
Publication Date(Web):October 2014
DOI:10.1016/j.cclet.2014.05.008
MCRs for preparation of chromenopyridines under reflux conditions and chromenes at room temperature conditions from different salicylaldehydes, malononitrile and different thiols (mol ratio = 1:2:1) were established. Mechanistic investigation suggests that the MCRs undergo different pathways at different temperatures and catalyzed by different organic bases. The structure of chromenopyridine and chromene are confirmed by crystal X-ray crystallography.MCRs for preparation of chromenopyridines under reflux conditions and chromenes at room temperature conditions, respectively, from different salicylaldehydes, malononitrile and different thiols (mol ratio = 1:2:1) were established.
1-(4-hydroxy-3-methoxyphenyl)-3-(2,4,6-trimethoxyphenyl)propan-1-one
1-(4-hydroxy-3-methoxyphenyl)-3-(2,4,6-trimethoxyphenyl)propan-1-one
CAS:1509963-13-6
1-(4-hydroxy-3-methoxyphenyl)-3-(2,4,6-trimethoxyphenyl)propan-1-one
2-[3-(benzo[d][1,3]dioxol-5-yl)-3-oxopropyl]-3,5-dimethoxycyclohexa-2,5-diene-1,4-dione
2-[3-(benzo[d][1,3]dioxol-5-yl)-3-oxopropyl]-3,5-dimethoxycyclohexa-2,5-diene-1,4-dione
CAS:1509963-10-3
2-[3-(benzo[d][1,3]dioxol-5-yl)-3-oxopropyl]-3,5-dimethoxycyclohexa-2,5-diene-1,4-dione
1-(5-hydroxy-2,4-dimethoxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)propane
1-(5-hydroxy-2,4-dimethoxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)propane
CAS:1443655-54-6
1-(5-hydroxy-2,4-dimethoxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)propane
1H-1,2,3-Triazole, 4-(4-fluorophenyl)-1-phenyl-
1H-1,2,3-Triazole, 4-(4-fluorophenyl)-1-phenyl-
CAS:1424335-89-6
1H-1,2,3-Triazole, 4-(4-fluorophenyl)-1-phenyl-
1H-1,2,3-Triazole, 1-[4-(1-methylethyl)phenyl]-4-phenyl-
1H-1,2,3-Triazole, 1-[4-(1-methylethyl)phenyl]-4-phenyl-
CAS:1423041-58-0
1H-1,2,3-Triazole, 1-[4-(1-methylethyl)phenyl]-4-phenyl-
1-(3-hydroxy-2,4-dimethoxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)propane
1-(3-hydroxy-2,4-dimethoxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)propane
CAS:1335028-50-6
1-(3-hydroxy-2,4-dimethoxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)propane
1-(4-hydroxy-2,5-dimethoxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)propane
1-(4-hydroxy-2,5-dimethoxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)propane
CAS:1335028-49-3
1-(4-hydroxy-2,5-dimethoxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)propane
1H-1,2,3-Triazole, 1-(3-methoxyphenyl)-4-phenyl-
1H-1,2,3-Triazole, 1-(3-methoxyphenyl)-4-phenyl-
CAS:1259900-48-5
1H-1,2,3-Triazole, 1-(3-methoxyphenyl)-4-phenyl-
1H-Isoindole-1,3(2H)-dione, 5-methyl-2-(2-propyn-1-yl)-
1H-Isoindole-1,3(2H)-dione, 5-methyl-2-(2-propyn-1-yl)-
CAS:1250779-15-7
1H-Isoindole-1,3(2H)-dione, 5-methyl-2-(2-propyn-1-yl)-
CAS:1233956-20-1