•An efficient synthesis of α-trifluoromethylseleno-substituted ketones is developed.•A variety of functional groups are well tolerated.•The reaction is amenable to scale up.Herein we disclose the report on the synthesis of α-trifluoromethylseleno-substituted ketone derivatives via copper-mediated trifluoromethylselenolation of α-bromoketones with [(bpy)Cu(SeCF3)]2 1. A broad range of substituted 2-bromoacetophenone substrates were found to react smoothly with 1 in the presence of 3 equiv of K3PO4 to afford the corresponding α-trifluoromethylseleno-substituted ketones in good yields. A wide range of functional groups were well tolerated and the reaction conditions are amenable to scale up.Download high-res image (75KB)Download full-size image

•An efficient synthesis of α-trifluoroethoxy-substituted ketones has been developed.•The trifluoroethoxy-substituted pyrazoles synthesis has also been demonstrated.•A wide range of important functional groups are compatible with this reaction.A mild and straight-forward synthesis of α-trifluoroethoxy-substituted ketones from the trifluoroethoxylation of α-bromoketones with trifluoroethanol, under Cs2CO3-mediated conditions at room temperature, is described. The utility of this reaction for the synthesis of the trifluoroethoxy-substituted alcohols and pyrazoles is also showed. The reaction tolerates various functional groups and demonstrates efficient scalability and practicality.A mild and straight-forward synthesis of α-trifluoroethoxy-substituted ketones has been developed. The utility of this reaction for synthesis of the trifluoroethoxy-substituted alcohols and pyrazoles has also been demonstrated.

•A direct Pd-catalyzed desulfitative cross-coupling of polyfluoroarenes with various arylsulfinate salts to afford fluorinated biaryls has been described.•This reaction was accelerated by trace amount of water.•Several functional groups are compatible with this reaction.A new approach to the synthesis of fluorinated biaryl compounds from easily available starting materials is described. This protocol is based on the direct palladium-catalyzed desulfitative cross-coupling of polyfluoroarenes with various arylsulfinate salts via CH bond activation, accelerated by trace amount of water. The method allows the synthesis of various fluorinated biaryl products in moderate to good yields, and tolerated a variety of functional groups, including alkyl, phenyl, methoxy, fluoro, and chloro groups.A new approach to the synthesis of fluorinated biaryl compounds from easily available starting materials is described. This protocol is based on the direct palladium-catalyzed desulfitative cross-coupling of polyfluoroarenes with various arylsulfinate salts via CH bond activation, accelerated by trace amount of water. The method allows the synthesis of various fluorinated biaryl products in moderate to good yields, and tolerated a variety of functional groups, including alkyl, phenyl, methoxy, fluoro, chloro, and nitro groups.