Qian Zhang

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Name: 张前; Zhang, Qian

Organization: Northeast Normal University , China

Department: Department of Chemistry

Title: NULL(PhD)

TOPICS

Organic Chemistry

Chemicals
References

Copper-Catalyzed Imidovinylation of Alkynes via 1,3-Vinyl Migration

Co-reporter:Jiaqiong Sun, Guangfan Zheng, Qiao Zhang, Yimin Wang, Shengbiao Yang, Qian Zhang, Yan Li, and Qian Zhang

Organic Letters July 21, 2017 Volume 19(Issue 14) pp:3767-3767

Publication Date(Web):July 6, 2017

DOI:10.1021/acs.orglett.7b01599

The first copper-catalyzed imidovinylation of alkynes has been developed, which grants facile access to various (E)-2-imido-2,4-dienals with high stereoselectivity under mild conditions. This transformation also represents the first 1,3-carbon migration of propargylic alcohols and their derivatives.

Metal-Free Three-Component Regioselective Aminofluorination of Styrene Derivatives

Co-reporter:Qiao Zhang, Guangfan Zheng, Qian Zhang, Yan Li, and Qian Zhang

The Journal of Organic Chemistry August 4, 2017 Volume 82(Issue 15) pp:8258-8258

Publication Date(Web):July 18, 2017

DOI:10.1021/acs.joc.7b01089

The first metal-free, three-component radical aminofluorination of styrene derivatives has been developed, which employs Selectfluor as a fluorine source and azole derivatives as a nitrogen source. This transformation proceeds with high regioselectivity, providing various 1,2-aminofluorination compounds under mild conditions. Mechanistic studies suggest that the aminofluorination process might involve radical fluorination followed by nucleophilic amination.

Cu-Catalyzed Aminodifluoroalkylation of Alkynes and α-Bromodifluoroacetamides

Co-reporter:Yunhe Lv, Weiya Pu, Qian Chen, Qingqing Wang, Jiejie Niu, and Qian Zhang

The Journal of Organic Chemistry August 4, 2017 Volume 82(Issue 15) pp:8282-8282

Publication Date(Web):July 10, 2017

DOI:10.1021/acs.joc.7b01313

The copper-catalyzed highly regioselective aminodifluoroalkylation of alkynes and α-bromodifluoroacetamides was realized for the first time. With this method, 3,3-difluoro-1H-pyrrol-2(3H)-ones were constructed in a single step from various alkynes and α-bromodifluoroacetamides substrates without using any extra oxidant.

Asymmetric Nitrone Synthesis via Ligand-Enabled Copper-Catalyzed Cope-Type Hydroamination of Cyclopropene with Oxime

Co-reporter:Zhanyu Li, Jinbo Zhao, Baozhen Sun, Tingting Zhou, Mingzhu Liu, Shuang Liu, Mengru Zhang, and Qian Zhang

Journal of the American Chemical Society August 30, 2017 Volume 139(Issue 34) pp:11702-11702

Publication Date(Web):August 7, 2017

DOI:10.1021/jacs.7b06523

We report realization of the first enantioselective Cope-type hydroamination of oximes for asymmetric nitrone synthesis. The ligand promoted asymmetric cyclopropene “hydronitronylation” process employs a Cu-based catalytic system and readily available starting materials, operates under mild conditions and displays broad scope and exceptionally high enantio- and diastereocontrol. Preliminary mechanistic studies corroborate a CuI-catalytic profile featuring an olefin metalla-retro-Cope aminocupration process as the key C–N bond forming event. This conceptually novel reactivity enables the first example of highly enantioselective catalytic nitrone formation process and will likely spur further developments that may significantly expedite chiral nitrone synthesis.

Copper-Catalyzed Aminodifluoroalkylation of Alkenes with α-Bromodifluoroacetamides: Synthesis of 3,3-Difluoropyrrolidin-2-ones

Co-reporter:Yunhe Lv;Weiya Pu;Qingqing Wang;Qian Chen;Jiejie Niu

Advanced Synthesis & Catalysis 2017 Volume 359(Issue 18) pp:3114-3119

Publication Date(Web):2017/09/18

DOI:10.1002/adsc.201700559

AbstractCopper-catalyzed external-oxidant-free regioselective aminodifluoroalkylation of alkenes with readily available α-bromodifluoroacetamides was realized. This reaction exhibits good functional group tolerance with respect to alkenes and α-bromodifluoroacetamides in affording 3,3-difluoropyrrolidin-2-ones. A mechanism involving copper-catalyzed generation of a difluoroalkyl radical is proposed.

Copper-catalyzed oxidative amidation of α,β-unsaturated ketones via selective C–H or C–C bond cleavage

Co-reporter:Tony Wheellyam Pouambeka;Ge Zhang;Guang-Fan Zheng;Guo-Xing Xu;Tao Xiong

Organic Chemistry Frontiers 2017 vol. 4(Issue 7) pp:1420-1424

Publication Date(Web):2017/06/27

DOI:10.1039/C7QO00146K

The copper-catalyzed oxidative amidation of readily available α,β-unsaturated ketones with N-fluorobenzenesulfonimide (NFSI) for the synthesis of biologically active enamides or α-amino substituted unsaturated ketone skeletons has been achieved. These transformations processed via a radical pathway, thus the amidation occurred at the unusual α-position of the α,β-unsaturated ketones, leading to the following effective C(CO)–C(vinyl) or C(vinyl)–H bond cleavage with high selectivity.

Copper-Catalyzed Three Component Regio- and Stereospecific Selenosulfonation of Alkynes: Synthesis of (E)-β-Selenovinyl Sulfones

Co-reporter:Yang Liu, Guangfan Zheng, Qian Zhang, Yan LiQian Zhang

The Journal of Organic Chemistry 2017 Volume 82(Issue 4) pp:

Publication Date(Web):January 26, 2017

DOI:10.1021/acs.joc.6b03049

A copper-catalyzed highly regio- and stereospecific selenosulfonation of alkynes with arylsulfonohydrazides and diphenyl diselenide has been developed. This novel three component reaction proceeds under very mild conditions and with a broad scope of substrates, providing a wide range of (E)-β-selenovinyl sulfones in good to excellent yields.

New amination strategies based on nitrogen-centered radical chemistry

Co-reporter:Tao Xiong and Qian Zhang

Chemical Society Reviews 2016 vol. 45(Issue 11) pp:3069-3087

Publication Date(Web):27 Apr 2016

DOI:10.1039/C5CS00852B

The interesting and diverse biological activities of nitrogen-containing compounds make the construction of the C–N bond of great importance. Despite the tremendous advances that have been made in this research field, C–N bond formation based on nitrogen-centered radicals remains a significant challenge due to the harsh conditions required for the generation of nitrogen-centered radicals and their propensity for hydrogen abstraction or engaging in other degradation pathways. In the past several years, novel methodologies for C–N bond constructions based on nitrogen centered-radical intermediates, coordinated with metal or generated in the presence of visible-light and a photocatalyst, have attracted considerable attention. This tutorial review will summarize the significant progress of these efficient and mild radical amination reactions, with an emphasis on approaches for the generation of nitrogen-centered radicals and their reaction patterns, related mechanisms and synthetic applications, as well as unmet challenges in this emerging and promising field.

Catalytically Generated Allyl Cu(I) Intermediate via Cyclopropene Ring-Opening Coupling en Route to Allylphosphonates

Co-reporter:Zhanyu Li, Guochun Peng, Jinbo Zhao, and Qian Zhang

Organic Letters 2016 Volume 18(Issue 19) pp:4840-4843

Publication Date(Web):September 22, 2016

DOI:10.1021/acs.orglett.6b02307

An efficient generation of functionalized allyl copper(I) species via cyclopropene ring-opening coupling reaction is reported, which enables stereoselective access to allylphosphonates. Mechanistic studies uncovered stereochemistry to be controlled by both ligand and substrate electronics, with the latter likely arising from pronounced arene-Cu(I) interaction in electron-deficient substrates. The study unravels a novel approach to access functionalized nucleophilic allylcopper species upon which three-component coupling reactions might be developed.

Highly Regio- and Stereoselective Intermolecular Seleno- and Thioamination of Alkynes

Co-reporter:Guangfan Zheng;Jinbo Zhao;Zhanyu Li;Qiao Zhang;Jiaqiong Sun;Haizhu Sun

Chemistry - A European Journal 2016 Volume 22( Issue 10) pp:3513-3518

Publication Date(Web):

DOI:10.1002/chem.201504534

Abstract

By using N-fluorobenzenesulfonimide as both the oxidant and the amination reagent, we have realized the first example of the intermolecular chalcogenative amination of alkynes, which grants facile, highly regio- and stereoselective access to chalcogenated enamides. The reaction features mild conditions, high yields and selectivities, remarkably broad substrate scope, and excellent functional group tolerance. Mechanistic studies indicate the in situ generated chalcogen imidates to be the actual reactive species, which in turn, has clarified the mechanism of related transformations. These reactions represent significant additions to the development of the highly selective amino bisfunctionalization of alkynes.

Copper-catalyzed arenes amination with saccharins

Co-reporter:Kai Sun;Yan Li

Science China Chemistry 2015 Volume 58( Issue 8) pp:1354-1358

Publication Date(Web):2015 August

DOI:10.1007/s11426-015-5385-y

A novel copper-catalyzed direct C-N formation reaction of simple arenes with cheap and pharmacological saccharin derivatives under relatively mild conditions was developed with arenes as limiting reagents. This work provided a new method for oxidative coupling of aromatic C(sp2)-H bonds and N-H bonds.

Highly Regioselective Radical Amination of Allenes: Direct Synthesis of Allenamides and Tetrasubstituted Alkenes

Co-reporter:Ge Zhang; Tao Xiong;Zining Wang;Guoxing Xu;Xuedan Wang ; Qian Zhang

Angewandte Chemie 2015 Volume 127( Issue 43) pp:12840-12844

Publication Date(Web):

DOI:10.1002/ange.201506066

Abstract

The first controllable, regioselective radical amination of allenes with N-fluoroarylsulfonimide is described to proceed under very mild reaction conditions. With this methodology, a general and straightforward route for the synthesis of both allenamides and fluorinated tetrasubstituted alkenes was realized from a wide range of terminal and internal allenes.

Highly Regioselective Radical Amination of Allenes: Direct Synthesis of Allenamides and Tetrasubstituted Alkenes

Co-reporter:Ge Zhang; Tao Xiong;Zining Wang;Guoxing Xu;Xuedan Wang ; Qian Zhang

Angewandte Chemie International Edition 2015 Volume 54( Issue 43) pp:12649-12653

Publication Date(Web):

DOI:10.1002/anie.201506066

Abstract

nBu4NI-Catalyzed oxidative imidation of ketones with imides: synthesis of α-amino ketones

Co-reporter:Yunhe Lv, Yan Li, Tao Xiong, Yu Lu, Qun Liu and Qian Zhang

Chemical Communications 2014 vol. 50(Issue 18) pp:2367-2369

Publication Date(Web):09 Jan 2014

DOI:10.1039/C3CC48887J

nBu4NI-Catalyzed oxidative imidation of ketones and imides for the synthesis of α-amino ketones were realized for the first time. The methodology is characterized by its wide substrate scope even for acetone with readily available phthalimide, saccharin and succinimide, which opens a new pathway for direct imidation of ketones.

Hydroxyamination of aryl C–H bonds with N-hydroxycarbamate by synergistic Rh/Cu catalysis at room temperature

Co-reporter:Wei Yang, Jiaqiong Sun, Xianxiu Xu, Qian Zhang and Qun Liu

Chemical Communications 2014 vol. 50(Issue 34) pp:4420-4422

Publication Date(Web):13 Jan 2014

DOI:10.1039/C3CC49496A

A novel hydroamination of aryl C–H bonds has been accomplished using N-Boc-hydroxyamine via synergistic combination of rhodium and copper catalysis. The merger of two robust catalytic systems has allowed for the development of a mild and sustainable protocol for the direct formation of benzo[c]isoxazol-3(1H)-ones.

Regioselective Radical Aminofluorination of Styrenes

Co-reporter:Hongwei Zhang;Yongcheng Song;Dr. Jinbo Zhao; Jingping Zhang; Qian Zhang

Angewandte Chemie International Edition 2014 Volume 53( Issue 41) pp:11079-11083

Publication Date(Web):

DOI:10.1002/anie.201406797

Abstract

The copper-catalyzed radical aminofluorination of styrenes with N-fluorobenzenesulfonimide (NFSI) is realized with high regioselectivity, thus affording aminofluorination products with regioselectivities opposite that of the palladium-catalyzed and noncatalyzed processes. Preliminary mechanistic studies suggested the reaction went through a radical pathway and was supported by DFT calculations. In these reactions, NFSI is utilized as both a radical nitrogen source and radical fluorine source, thus rendering it an attractive reagent.

Reductive amination of tertiary anilines and aldehydes

Co-reporter:Yunhe Lv, Yiying Zheng, Yan Li, Tao Xiong, Jingping Zhang, Qun Liu and Qian Zhang

Chemical Communications 2013 vol. 49(Issue 78) pp:8866-8868

Publication Date(Web):21 Aug 2013

DOI:10.1039/C3CC45084H

An unprecedented oxidant-mediated reductive amination of tertiary anilines and aldehydes without external reducing agents was developed via the nucleophilic attack of the oxygen atom of the carbonyl group to in situ generated iminium ions, in which tertiary anilines were used as both nitrogen source and reducing agent for the first time.

Copper-catalyzed annulation of amidines for quinazoline synthesis

Co-reporter:Yunhe Lv, Yan Li, Tao Xiong, Weiya Pu, Hongwei Zhang, Kai Sun, Qun Liu and Qian Zhang

Chemical Communications 2013 vol. 49(Issue 57) pp:6439-6441

Publication Date(Web):30 May 2013

DOI:10.1039/C3CC43129K

An efficient Cu-catalyzed synthesis of quinazolines via the C–N bond formation reactions between N–H bonds of amidines and C(sp3)–H bonds adjacent to sulfur or nitrogen atoms in the commonly used solvents, such as DMSO, DMF, DMA, NMP or TMEDA, followed by intramolecular C–C bond formation reactions was developed for the first time.

Investigation on the mechanism of water-assisted palladium-catalyzed benzylic C–H amination by N-fluorobenzenesulfonimide

Co-reporter:Yiying Zheng, Tao Xiong, Yunhe Lv, Jingping Zhang and Qian Zhang

Organic & Biomolecular Chemistry 2013 vol. 11(Issue 45) pp:7923-7930

Publication Date(Web):19 Sep 2013

DOI:10.1039/C3OB41299G

A combination of computational and experimental methods was carried out to elucidate the mechanism of palladium-catalyzed water-assisted benzylic C–H amination with N-fluorobenzenesulfonimide (NFSI), which involved the oxidative addition of PdII to PdIV-species as a rate-limiting step, followed by water-assisted concerted metalation–deprotonation (CMD) of the PdIV complex and water-assisted reductive elimination (RE) processes, and then a nucleophilic addition process to generate the final product and complete the catalytic cycle. The stability of the PdIV complex could be ascribed to the suitable ligands with strong σ-donors and resistance to decomposition, as well as being sufficiently bulky because the water-clusters assembled the ligands through hydrogen bonds to act as one multidentate ligand. Calculation results suggested that water also plays a crucial role as a proton transferring bridge in water-assisted CMD and RE processes. The corresponding experimental findings substantiate the expectation. Additionally, NFSI was found to act as both the oxidant and the nitrogen source to facilitate the reaction, while the steric effect of the bulky –N(SO2Ph)2 group contributed to circumventing the o-C–H amination. In this reaction, we investigated a novel spiro-cyclopalladation intermediate, formed by the reaction of the PdIV centre with pristine-carbon instead of ortho-carbon, which might be valuable for our understanding and further development of transition metal catalyzed C–H functionalization.

Silver-Catalyzed Isocyanide-Alkyne Cycloaddition: A General and Practical Method to Oligosubstituted Pyrroles

Co-reporter:Jianquan Liu;Zhongxue Fang; Qian Zhang; Qun Liu; Xihe Bi

Angewandte Chemie International Edition 2013 Volume 52( Issue 27) pp:6953-6957

Publication Date(Web):

DOI:10.1002/anie.201302024

Copper-Catalyzed Intermolecular Aminocyanation and Diamination of Alkenes

Co-reporter:Hongwei Zhang;Weiya Pu;Dr. Tao Xiong;Dr. Yan Li;Xue Zhou;Kai Sun;Dr. Qun Liu ;Dr. Qian Zhang

Angewandte Chemie International Edition 2013 Volume 52( Issue 9) pp:2529-2533

Publication Date(Web):

DOI:10.1002/anie.201209142

Synthesis of Tetramic Acid Derivatives via Intramolecular sp3 C–H Amination Mediated by Hypervalent Iodine(III) Reagents/Brønsted Acids

Co-reporter:Lujia Mao, Yan Li, Tao Xiong, Kai Sun, and Qian Zhang

The Journal of Organic Chemistry 2013 Volume 78(Issue 2) pp:733-737

Publication Date(Web):December 13, 2012

DOI:10.1021/jo302144w

An efficient synthesis of tetramic acid derivatives was developed via intramolecular sp3 C–H aminations of 1-acetyl N-aryl cyclopropane/cyclopentanecarboxamides in the presence of PhI(OPiv)2 and CH3CH2COOH.

Palladium-catalyzed allylic C–H amination of alkenes with N-fluorodibenzenesulfonimide: water plays an important role

Co-reporter:Tao Xiong, Yan Li, Lujia Mao, Qian Zhang and Qian Zhang

Chemical Communications 2012 vol. 48(Issue 16) pp:2246-2248

Publication Date(Web):17 Jan 2012

DOI:10.1039/C2CC16720D

A new palladium-catalyzed highly regioselective allylic C–H amination of alkenes with NFSI in the presence of a catalytic amount of water was developed and successfully expanded to Selectfluor-mediated palladium-catalyzed aminations of alkenes with N-tosylcarbamates in water at room temperature.

Copper-Catalyzed Selective Benzylic C–O Cyclization of N-o-Tolylbenzamides: Synthesis of 4H-3,1-Benzoxazines

Co-reporter:Yan Li, Zhongshu Li, Tao Xiong, Qian Zhang, and Xiangyang Zhang

Organic Letters 2012 Volume 14(Issue 13) pp:3522-3525

Publication Date(Web):June 22, 2012

DOI:10.1021/ol301492d

A novel Selectfluor-mediated copper-catalyzed highly selective benzylic C–O cyclization for the synthesis 4H-3,1-benzoxazines is reported. The predominant selectivity for a benzylic C(sp3)–H over an aromatic C(sp2)–H bond in N-o-tolylbenzamides is achieved.

Highly Regioselective Copper-Catalyzed Benzylic CH Amination by N-Fluorobenzenesulfonimide

Co-reporter:Zhikun Ni;Dr. Qian Zhang;Tao Xiong;Yiying Zheng;Yan Li;Hongwei Zhang;Dr. Jingping Zhang;Dr. Qun Liu

Angewandte Chemie International Edition 2012 Volume 51( Issue 5) pp:1244-1247

Publication Date(Web):

DOI:10.1002/anie.201107427

Highly Regioselective Copper-Catalyzed Benzylic CH Amination by N-Fluorobenzenesulfonimide

Co-reporter:Zhikun Ni;Dr. Qian Zhang;Tao Xiong;Yiying Zheng;Yan Li;Hongwei Zhang;Dr. Jingping Zhang;Dr. Qun Liu

Angewandte Chemie 2012 Volume 124( Issue 5) pp:1270-1273

Publication Date(Web):

DOI:10.1002/ange.201107427

Palladium-Catalyzed C−H Aminations of Anilides with N-Fluorobenzenesulfonimide

Co-reporter:Kai Sun ; Yan Li ; Tao Xiong ; Jingping Zhang

Journal of the American Chemical Society 2011 Volume 133(Issue 6) pp:1694-1697

Publication Date(Web):January 20, 2011

DOI:10.1021/ja1101695

The first amide-directed, palladium-catalyzed, intermolecular, highly selective C−H aminations with the non-nitrene-based nitrogen source N-fluorobenzenesulfonimide have been developed. This methodology might provide a new pathway for directed metal-catalyzed aromatic C−H amination.

Cu2O acting as a robust catalyst in CuAAC reactions: water is the required medium

Co-reporter:Kai Wang, Xihe Bi, Shuangxi Xing, Peiqiu Liao, Zhongxue Fang, Xianyu Meng, Qian Zhang, Qun Liu and Yu Ji

Green Chemistry 2011 vol. 13(Issue 3) pp:562-565

Publication Date(Web):25 Jan 2011

DOI:10.1039/C0GC00848F

Cu2O as the catalyst in water was found to be quite robust for the azide-alkyne cycloaddition (AAC) reaction, which was verified by a wide variety of applicable azides and alkynes. Water was proved to play an essential role because of a significant rate acceleration compared with reactions using organic solvents and conducted under neat conditions. The high catalytic performance of Cu2O/H2O system was further argued by decreasing the catalyst loading to ppm levels.

Iron-catalyzed synthesis of polysubstituted pyrrolesvia [4C+1N] cyclization of 4-acetylenic ketones with primary amines

Co-reporter:Yeming Wang, Xihe Bi, Dehua Li, Peiqiu Liao, Yidong Wang, Jin Yang, Qian Zhang and Qun Liu

Chemical Communications 2011 vol. 47(Issue 2) pp:809-811

Publication Date(Web):11 Nov 2010

DOI:10.1039/C0CC03802D

A highly efficient iron-catalyzed approach to polysubstituted pyrroles has been developed through the [4C+1N] cyclization of 4-acetylenic ketones with primary amines, leading to the synthesis of a variety of tetra- and fully-substituted pyrroles as well as fused pyrrole derivatives in good to excellent yields.

Copper-Catalyzed Dehydrogenative Cross-Coupling Reactions of N-para-Tolylamides through Successive CH Activation: Synthesis of 4H-3,1-Benzoxazines

Co-reporter:Tao Xiong;Yan Li;Dr. Xihe Bi;Yunhe Lv ;Dr. Qian Zhang

Angewandte Chemie International Edition 2011 Volume 50( Issue 31) pp:7140-7143

Publication Date(Web):

DOI:10.1002/anie.201101391

Remote amide-directed palladium-catalyzed benzylic C–H amination with N-fluorobenzenesulfonimide

Co-reporter:Tao Xiong, Yan Li, Yunhe Lv and Qian Zhang

Chemical Communications 2010 vol. 46(Issue 36) pp:6831-6833

Publication Date(Web):18 Aug 2010

DOI:10.1039/C0CC02175J

An unprecedented remote amide-directed palladium-catalyzed intermolecular highly selective benzylic C–H amination with N-fluorobenzenesulfonimide is developed, which represents the first direct benzylic C–H amination with a non-nitrene nitrogen source. This methodology provides a novel approach to circumvent the common ortho aromatic C–H selectivity in directed palladium catalyzed C–H functionalization.

Ag-containing all-carbon 1,3-dipoles: generation and formal cycloaddition for furo[3,2-b]-β/γ-lactams

Co-reporter:Zhiguo Zhang, Qian Zhang, Zhikun Ni and Qun Liu

Chemical Communications 2010 vol. 46(Issue 8) pp:1269-1271

Publication Date(Web):16 Jan 2010

DOI:10.1039/B917856B

A new strategy for highly diastereoselective synthesis of furo[3,2-b]-β-lactams and furo[3,2-b]-γ-lactams via a novel Ag(I)-mediated intramolecular 1,3-dipolar cycloaddition of oxo-N-propargylamides, is developed and the possible mechanism of these transformation is proposed.

Domino Ring-Opening/Recyclization Reactions of Doubly Activated Cyclopropanes as a Strategy for the Synthesis of Furoquinoline Derivatives

Co-reporter:Zhiguo Zhang Dr. ;Shaoguang Sun Dr.;Tao Xiong;Qun Liu

Angewandte Chemie International Edition 2007 Volume 46(Issue 10) pp:

Publication Date(Web):19 JAN 2007

DOI:10.1002/anie.200604276

In one easy step, doubly activated cyclopropanes 1 can be transformed into furoquinoline derivatives 2 through a tandem ring-opening/recyclization reaction mediated by SnCl₄⋅5 H₂O. A variety of substrates 1 derived from cheap starting materials were converted into the corresponding furoquinolines in good to excellent yields with high chemo- and regioselectivity. R=H, Me, OMe, Cl, or aromatic group is naphthyl.

Domino Ring-Opening/Recyclization Reactions of Doubly Activated Cyclopropanes as a Strategy for the Synthesis of Furoquinoline Derivatives

Co-reporter:Zhiguo Zhang Dr. ;Shaoguang Sun Dr.;Tao Xiong;Qun Liu

Angewandte Chemie 2007 Volume 119(Issue 10) pp:

Publication Date(Web):19 JAN 2007

DOI:10.1002/ange.200604276

Ein einziger einfacher Schritt – eine Tandem-Ringöffnung/Recyclisierung, vermittelt durch SnCl₄⋅5 H₂O – führt von doppelt aktivierten Cyclopropanen 1 zu Furochinolinderivaten 2. Mit billigen Ausgangsverbindungen wurde eine Vielzahl an Substraten 1 erhalten, die in guten bis ausgezeichneten Ausbeuten und mit hoher Chemo- und Regioselektivität die entsprechenden Furochinoline ergaben. R=H, Me, OMe, Cl oder Naphthyl als Arylrest.

Synthesis and Characteristics of Hole-transporting Materials Based on Biphenyl Diamine Derivatives with Carbazole Groups

Co-reporter:Qian ZHANG, Jiang-shan CHEN, Yan-xiang CHENG, Li-xiang WANG, Dong-ge MA, Xia-bin JING, Fo-song WANG

Chemical Research in Chinese Universities 2006 Volume 22(Issue 5) pp:647-650

Publication Date(Web):September 2006

DOI:10.1016/S1005-9040(06)60181-5

Ag-containing all-carbon 1,3-dipoles: generation and formal cycloaddition for furo[3,2-b]-β/γ-lactams

Co-reporter:Zhiguo Zhang, Qian Zhang, Zhikun Ni and Qun Liu

Chemical Communications 2010 - vol. 46(Issue 8) pp:NaN1271-1271

Publication Date(Web):2010/01/16

DOI:10.1039/B917856B

Palladium-catalyzed allylic C–H amination of alkenes with N-fluorodibenzenesulfonimide: water plays an important role

Co-reporter:Tao Xiong, Yan Li, Lujia Mao, Qian Zhang and Qian Zhang

Chemical Communications 2012 - vol. 48(Issue 16) pp:NaN2248-2248

Publication Date(Web):2012/01/17

DOI:10.1039/C2CC16720D

Reductive amination of tertiary anilines and aldehydes

Co-reporter:Yunhe Lv, Yiying Zheng, Yan Li, Tao Xiong, Jingping Zhang, Qun Liu and Qian Zhang

Chemical Communications 2013 - vol. 49(Issue 78) pp:NaN8868-8868

Publication Date(Web):2013/08/21

DOI:10.1039/C3CC45084H

Copper-catalyzed annulation of amidines for quinazoline synthesis

Co-reporter:Yunhe Lv, Yan Li, Tao Xiong, Weiya Pu, Hongwei Zhang, Kai Sun, Qun Liu and Qian Zhang

Chemical Communications 2013 - vol. 49(Issue 57) pp:NaN6441-6441

Publication Date(Web):2013/05/30

DOI:10.1039/C3CC43129K

Copper-catalyzed oxidative amidation of α,β-unsaturated ketones via selective C–H or C–C bond cleavage

Co-reporter:Tony Wheellyam Pouambeka, Ge Zhang, Guang-Fan Zheng, Guo-Xing Xu, Qian Zhang, Tao Xiong and Qian Zhang

Inorganic Chemistry Frontiers 2017 - vol. 4(Issue 7) pp:

Publication Date(Web):

DOI:10.1039/C7QO00146K

Hydroxyamination of aryl C–H bonds with N-hydroxycarbamate by synergistic Rh/Cu catalysis at room temperature

Co-reporter:Wei Yang, Jiaqiong Sun, Xianxiu Xu, Qian Zhang and Qun Liu

Chemical Communications 2014 - vol. 50(Issue 34) pp:NaN4422-4422

Publication Date(Web):2014/01/13

DOI:10.1039/C3CC49496A

nBu4NI-Catalyzed oxidative imidation of ketones with imides: synthesis of α-amino ketones

Co-reporter:Yunhe Lv, Yan Li, Tao Xiong, Yu Lu, Qun Liu and Qian Zhang

Chemical Communications 2014 - vol. 50(Issue 18) pp:NaN2369-2369

Publication Date(Web):2014/01/09

DOI:10.1039/C3CC48887J

Iron-catalyzed synthesis of polysubstituted pyrrolesvia [4C+1N] cyclization of 4-acetylenic ketones with primary amines

Co-reporter:Yeming Wang, Xihe Bi, Dehua Li, Peiqiu Liao, Yidong Wang, Jin Yang, Qian Zhang and Qun Liu

Chemical Communications 2011 - vol. 47(Issue 2) pp:NaN811-811

Publication Date(Web):2010/11/11

DOI:10.1039/C0CC03802D

Remote amide-directed palladium-catalyzed benzylic C–H amination with N-fluorobenzenesulfonimide

Co-reporter:Tao Xiong, Yan Li, Yunhe Lv and Qian Zhang

Chemical Communications 2010 - vol. 46(Issue 36) pp:NaN6833-6833

Publication Date(Web):2010/08/18

DOI:10.1039/C0CC02175J

New amination strategies based on nitrogen-centered radical chemistry

Co-reporter:Tao Xiong and Qian Zhang

Chemical Society Reviews 2016 - vol. 45(Issue 11) pp:NaN3087-3087

Publication Date(Web):2016/04/27

DOI:10.1039/C5CS00852B

Investigation on the mechanism of water-assisted palladium-catalyzed benzylic C–H amination by N-fluorobenzenesulfonimide

Co-reporter:Yiying Zheng, Tao Xiong, Yunhe Lv, Jingping Zhang and Qian Zhang

Organic & Biomolecular Chemistry 2013 - vol. 11(Issue 45) pp:NaN7930-7930

Publication Date(Web):2013/09/19

DOI:10.1039/C3OB41299G

CAS:1268451-51-9

Benzamide-2,3,4,5,6-d5, N-methoxy-

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Benzamide, 4-iodo-N-methoxy-

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