Qingbiao Yang

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Name: 杨清彪; Yang, QingBiao

Organization: Jilin University , China

Department: Department of Chemistry

Title: Professor(PhD)

TOPICS

Organic Chemistry

Chemicals
References

A new turn-on fluorescent probe towards hypochlorite in living cells

Co-reporter:Jing Guo;Zhixiang Zhang;Ziyu Kuai;Rui Wang;Yaming Shan;Yaoxian Li

Analytical Methods (2009-Present) 2017 vol. 9(Issue 5) pp:864-870

Publication Date(Web):2017/02/02

DOI:10.1039/C6AY02819E

A novel turn-on fluorescent sensor (PIPH) based on phenanthroimidazole derivatives was successfully designed and synthesized. The probe shows high selectivity and sensitivity towards OCl− with approximately 20-fold fluorescence enhancement at 415 nm and the detection limit was measured to be 0.58 μM. Then through NMR spectra and high-resolution mass spectrometry, it was confirmed that the phenylhydrazine group of PIPH was decomposed by OCl−. The fluorescence enhancement mechanism of the probe was further investigated by theoretical calculations. Finally, Hela cells were applied in cell imaging. It was proved that the probe has potential capacity to detect hypochlorite in vivo.

A simple colorimetric and fluorescent probe with high selectivity towards cysteine over homocysteine and glutathione

Co-reporter:Jing Guo;Ziyu Kuai;Zhixiang Zhang;Yaming Shan;Yaoxian Li

RSC Advances (2011-Present) 2017 vol. 7(Issue 31) pp:18867-18873

Publication Date(Web):2017/03/28

DOI:10.1039/C6RA28829D

A novel fluorescent probe (AQDA) based on quinizarin is designed and synthesized. Owing to a nucleophilic addition and a specific intramolecular cyclization reaction, the probe displays high selectivity towards cysteine (Cys) relative to other natural amino acids. The maximum fluorescent intensity is 30-fold that of the initial value in the presence of 5.0 equiv. Cys, and its detection limit is 0.158 μM. The recognition mechanism is further confirmed through mass spectroscopy and proton nuclear magnetic resonance titration. Simultaneously, the fluorescence enhancement mechanism is characterized by theoretical calculations, and experimental data are consistent with the theoretical results. Finally, the cellular imaging experiment verifies that AQDA possesses the capacity to detect endogenous Cys in living cells.

A novel “turn-on” thiooxofluorescein-based colorimetric and fluorescent sensor for Hg2+ and its application in living cells

Co-reporter:Yusha Feng, Ziyu Kuai, Yan Song, Jing Guo, Qingbiao Yang, Yaming Shan, Yaoxian Li

Talanta 2017 Volume 170(Volume 170) pp:

Publication Date(Web):1 August 2017

DOI:10.1016/j.talanta.2017.03.099

•A novel “turn-on” thiooxofluorescein-based chemosensor was firstly designed and synthesized.•The sensor exhibited high sensitivity and selectivity toward Hg2+ over others metal ions.•The sensor can used to be as a reversible probe for Hg2+ ions and has short response time.•The sensor has low cytotoxicity and can be applied to visualize Hg2+ in living cells.A novel water-soluble fluorescent probe FLS2 based on the thiooxofluorescein derivative has been firstly designed and synthesized. UV–vis absorption and fluorescence spectra studies showed that the FLS2 as a colorimetric and ratiometric fluorescent probe exhibited high selectivity and sensitivity towards Hg2+, which was mainly attributed to the special binding with the receptor unit accompanied with the spirolactam ring-opening progress. In addition, the probe FLS2 could be used as a naked-eye indicator for Hg2+ with reversible response. It displayed approximate 37-fold fluorescent enhancement at 529 nm in the presence of only 2.0 equiv. Hg2+ and the detection limit was calculated at about 39 nM. What's more, cellular imaging experiment revealed that the sensor had excellent biocompatibility and low cytotoxicity that could be utilized for monitoring Hg2+ in living cells.Download high-res image (138KB)Download full-size image

Regenerable Fluorescent Nanosensors for Monitoring and Recovering Metal Ions Based on Photoactivatable Monolayer Self-Assembly and Host–Guest Interactions

Co-reporter:Wei Wang, Nai-Kei Wong, Mingda Sun, Chunqiu Yan, Siyuan Ma, Qingbiao Yang, and Yaoxian Li

ACS Applied Materials & Interfaces 2015 Volume 7(Issue 16) pp:8868

Publication Date(Web):April 7, 2015

DOI:10.1021/acsami.5b01509

Efficient detection, removal, and recovery of heavy metal ions from aqueous environments represents a technologically challenging and ecologically urgent question in the face of increasing metal-related pollution and poisoning across the globe. Although small-molecule and entrapment-based nanoparticle sensors have been extensively explored for metal detection, neither of these extant strategies satisfies the critical needs for high-performance sensors that are inexpensive, efficient, and recyclable. Here we first report the development of a regenerable fluorescent nanosensor system for the selective and sensitive detection of multiple heavy metal ions, based on light-switchable monolayer self-assembly and host–guest interactions. The system exploits photocontrolled inclusion and exclusion responses of an α-cyclodextrin (CD)-containing surface conjugated with photoisomerizable azobenzene as a supramolecular system that undergoes reversible assembly and disassembly. The metal nanosensors can be facilely fabricated and photochemically switched between three chemically distinct entities, each having an excellent capacity for selective detecting specific metal ions (namely, Cu2+, Fe3+, Hg2+) in a chemical system and in assays on actual water samples with interfering contaminants.Keywords: fluorescence; metal nanosensor; monolayer self-assembly; photochemistry; supramolecular materials;

A triphenylamine-based colorimetric and “turn-on” fluorescent probe for detection of cyanide anions in live cells

Co-reporter:Shaodan Wang, Hai Xu, Qingbiao Yang, Yan Song and Yaoxian Li

RSC Advances 2015 vol. 5(Issue 59) pp:47990-47996

Publication Date(Web):18 May 2015

DOI:10.1039/C5RA05807D

A colorimetric and “turn-on” fluorescent probe has been developed for the detection of cyanide anions. Cyanide was detected via the nucleophilic addition of cyanide to the indolium group of the probe, which resulted in a change from a purple colour to colourless and an enhancement in fluorescence. The probe showed a high sensitivity and selectivity for cyanide anions over other common anionic species in aqueous ethanol solution. The limit of detection was as low as 21 nM. A live cell imaging experiment demonstrated the practical value of this probe in tracing cyanide anions in biological systems.

Fluorescent magnetic nanosensors for Zn2+ and CN− in aqueous solution prepared from adamantane-modified fluorescein and β-cyclodextrin-modified Fe3O4@SiO2 via host–guest interactions

Co-reporter:Qiang Li, Yue Zhang, Yang Jin, Qingbiao Yang, Jianshi Du and Yaoxian Li

RSC Advances 2015 vol. 5(Issue 84) pp:68815-68821

Publication Date(Web):27 Jul 2015

DOI:10.1039/C5RA12258A

A novel multifunctional fluorescent chemosensor has been constructed with a highly selective “off–on” behavior, recoverability and recyclability based on β-CD/AD (adamantane) host–guest self-assembly interactions. Adamantane-modified fluorescein/cyclodextrin-modified Fe3O4@SiO2 inclusion complex magnetic nanoparticles (FFIC MNPs), which can provide a specific green fluorescence enhancement in response to Zn2+, have a detection limit of 4.5 × 10−7 mol L−1 in CH3CN:H2O (1:4, v/v). The spirolactam ring in the fluorophore moiety would be open with the introduction of Zn2+, while it could recover as long as the zinc in the complex is removed. Meanwhile, one gram of FFIC MNPs can adsorb 6.1 mg zinc. Therefore, the derivative chemosensors, FFIC MNPs–Zn, are available to respond to CN− due to the fluorescence quenching under UV (ultraviolet) radiation with a detection limit of 7.7 × 10−7 mol L−1. Furthermore, the FFIC MNPs exhibit great reusability and recyclability in aqueous solution on account of their magnetism and reproducibility. We recycle the residual MNPs to detect Zn2+ repeatedly for at least 4 times, after readily adsorbing the complex zinc with excess CN−, and the same principle also works in reverse. If the fluorophore moiety is inactive, we could also wash out the useless fluorescent molecules from the MNPs (hosts) and then reassemble new fluorescent small-molecules (guests) to maintain the efficient properties of the probe in responding to Zn2+ and CN− for at least 7 times.

Colorimetric magnetic microspheres as chemosensor for Cu2+ prepared from adamantane-modified rhodamine and β-cyclodextrin-modified Fe3O4@SiO2 via host–guest interaction

Co-reporter:Yue Zhang, Wei Wang, Qiang Li, Qingbiao Yang, Yaoxian Li, Jianshi Du

Talanta 2015 Volume 141() pp:33-40

Publication Date(Web):15 August 2015

DOI:10.1016/j.talanta.2015.03.015

•Host–guest interaction was used to prepare inclusion complex magnetic nanoparticles.•The selectivity for Cu2+ of nanoparticles was very high.•It has a high sensitivity and a low detection limit.•The nanoparticles can be regenerated with a high efficiency.•It can be used as a “naked eye” detector of Cu2+.Adamantane-modified salicylrhodamine B and β-cyclodextrin-modified Fe3O4@SiO2 were assemblied by host–guest interactions which induced novel inclusion complex magnetic nanoparticles (SFIC MNPs) colorimetric sensitive for Cu2+ being prepared. The MNPs exhibit a clear color change from colorless to pink selectively and sensitively with the addition of Cu2+ in the experiments of UV–visible spectra, and the detection limit measures up to 5.99×10−6 M in solutions of CH3CN–H2O =1:10. The SFIC magnetic nanoparticles are superparamagnetic according to magnetic measurements and can be separated and collected easily with a commercial magnet in nine seconds. In addition, the microspheres have also showed good ability of separating for other ions from aqueous solutions due to a large number of hydroxyl groups on the surface.

A new fluorescent and colorimetric sensor for hydrazine and its application in biological systems

Co-reporter:Mingda Sun, Jing Guo, Qingbiao Yang, Ning Xiao and Yaoxian Li

Journal of Materials Chemistry A 2014 vol. 2(Issue 13) pp:1846-1851

Publication Date(Web):10 Jan 2014

DOI:10.1039/C3TB21753A

Hydrazine is a very important industrial chemical and exhibits high toxicity to human beings. Here we have constructed a novel ICT-based fluorescence sensor with a high selectivity and sensitivity, rapid detection, and huge color-change. We used the sensor for hydrazine determination in live cells and also in live fish, and manufactured dipsticks using our sensor. The sensing mechanism is well rationalized with the aid of TD-DFT (time-dependent density functional theory) calculations.

A new colorimetric fluorescent sensor for ratiometric detection of cyanide in solution, test strips, and in cells

Co-reporter:Mingda Sun, Shaodan Wang, Qingbiao Yang, Xiaoliang Fei, Yaoxian Li and Yapeng Li

RSC Advances 2014 vol. 4(Issue 16) pp:8295-8299

Publication Date(Web):15 Jan 2014

DOI:10.1039/C3RA46741D

A new high selective and sensitive fluorescent sensor for the detection of cyanide was developed based on the nucleophilic attack of CN− with a color change from purple to colourless. The chemosensor was used for fabrication of test strips that can detect cyanide in aqueous samples. The living animal fluorescence experiment demonstrated the practical value of the sensor in tracing the CN− in biological systems.

Preparation of a new superhydrophobic nanofiber film by electrospinning polystyrene mixed with ester modified silicone oil

Co-reporter:Yan Song;Lige Wang;Xiuling Wang;Kun Bian;Yaoxian Li

Journal of Applied Polymer Science 2014 Volume 131( Issue 17) pp:

Publication Date(Web):

DOI:10.1002/app.40718

ABSTRACT

A new superhydrophobic nanofiber membrane with certain mechanical strength was prepared by electrospinning the polystyrene (PS) with ester modified silicone oil (EMSO). To increase the roughness and tensile strength, the EMSO with low energy as hydrophobic macromolecular substance was added into PS precursor solution. Then during the process of electrospinning, some of the ester modified silicone oil was distribution on the surface of substrate (PS) fiber films to generate double structure which leaded to the superhydrophobicity. We probed into the relationship between the surface wettability, morphologies, mechanical property, and the mass ratios of ester modified silicone oil /PS, and with the increasing of EMSO, the water CA value increased from 135 ± 0.5° to 152 ± 0.2°and the tensile strength grown from 0.23 MPa to 0.92 MPa. The film shows a network structure consisting of numerous randomly oriented fibers, the diameters of which changed from 0.5 μm to 2.0 μm belong to relatively big diameter fibers, which has great significance to the research of superhydrophobic membrane with big diameter fibers and also this method is easy, convenient and environment friendly. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 40718.

Fabrication of large-scale superhydrophobic composite films with enhanced tensile properties by multinozzle conveyor belt electrospinning

Co-reporter:Shuai Wang;Yubo Yang;Yang Zhang;Xiaoliang Fei;Chen Zhou;Yue Zhang;Yaoxian Li;Yan Song

Journal of Applied Polymer Science 2014 Volume 131( Issue 1) pp:

Publication Date(Web):

DOI:10.1002/app.39735

ABSTRACT

Large-scale superhydrophobic composite films with enhanced tensile properties were prepared by multinozzle conveyor belt electrospinning. First, a strategy of conveyor belt electrospinning was introduced for large-scale fabrication since the conveyor belt can expand the electrospinning area unlimitedly. During the electrospinning (or electrospraying) process, certain kinds of fibers are combined on the conveyor belt in one electrospinning (or electrospraying) step. The superhydrophobicity of electrospun film can be achieved by the presence of PS beads and bead-on-string PVDF fibers, while submicron PAN fibers are responsible for the improvement of mechanical properties. The result shows that CA value of the surface comprising of PS beads and bead-on-string PVDF fibers could reach up to 155.0°. As the submicron PAN fibers increased, the value of CA decreased, changing from 155.0° to 140.0°, meanwhile the tensile strength of composite film was enhanced from 1.14 to 4.12 MPa correspondingly which is beneficial to putting the films into practice. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 39735.

Fluorescent and colorimetric magnetic microspheres as nanosensors for Hg2+ in aqueous solution prepared by a sol–gel grafting reaction and host–guest interaction

Co-reporter:Wei Wang, Yue Zhang, Qingbiao Yang, Mingda Sun, Xiaoliang Fei, Yan Song, Yingmu Zhang and Yaoxian Li

Nanoscale 2013 vol. 5(Issue 11) pp:4958-4965

Publication Date(Web):08 Apr 2013

DOI:10.1039/C3NR00580A

Fluorescent sensing TSRh6G-β-cyclodextrin fluorophore/adamantane-modified inclusion complex magnetic nanoparticles (TFIC MNPs) have been synthesized via the cooperation of a host–guest interaction and sol–gel grafting reaction. Powder X-ray diffraction, transmission electron microscopy, Fourier transform infrared spectroscopy, and UV-visible absorption and emission spectroscopy have been employed to characterize the material. Fluorescence and UV-visible spectra have shown that the resultant multifunctional nanoparticle sensors exhibit selective ‘turn-on’ type fluorescent enhancements and a clear color change from light brown to pink with Hg2+. Owing to a larger surface area and high permeability, TFIC MNPs exhibit remarkable selectivity and sensitivity for Hg2+, and its detection limit measures up to the micromolar level in aqueous solution. Most importantly, magnetic measurements have shown that TFIC magnetic nanoparticles are superparamagnetic and they can be separated and collected easily using a commercial magnet. These results not only solve the limitations in practical sensing applications of nanosensors, but also enable the fabrication of other multifunctional nanostructure-based hybrid nanomaterials.

A reusable nanofibrous film chemosensor for highly selective and sensitive optical signaling of Cu2+ in aqueous media

Co-reporter:Wei Wang, Xiuling Wang, Qingbiao Yang, Xiaoliang Fei, Mingda Sun and Yan Song

Chemical Communications 2013 vol. 49(Issue 42) pp:4833-4835

Publication Date(Web):08 Apr 2013

DOI:10.1039/C3CC41317A

A novel surface modification strategy for an electrospun nanofibrous film was reported, allowing detection and removal of copper ions in the aqueous solution. This reusable dual fluorescent–colorimetric nanofibrous film can be utilized conveniently to achieve real-time naked-eye sensing in aqueous medium just like using a test paper.

Simple naphthalimide-based fluorescent sensor for highly sensitive and selective detection of Cd2+ and Cu2+ in aqueous solution and living cells

Co-reporter:Wei Wang, Qian Wen, Yue Zhang, Xiaoliang Fei, Yaoxian Li, Qingbiao Yang and Xiaoyi Xu

Dalton Transactions 2013 vol. 42(Issue 5) pp:1827-1833

Publication Date(Web):31 Oct 2012

DOI:10.1039/C2DT32279J

A novel naphthalimide-based fluorescent sensor bearing the N,N′-bis(salicylidene)diethylenetriamine receptor was developed, which exhibited dual signaling behaviors for Cd2+ and Cu2+, and was applicable to the environmental and biological milieus. Upon addition of Cd2+, the fluorescence intensity enhanced in a linear fashion with the maximum fluorescence intensity increase of about 4-fold. Moreover, with the sensor 1 and 1–Cd2+ complex, Cu2+ was easily recognized by marked fluorescence quenching. The selectivity and sensitivity of the sensor 1 for Cd2+ were satisfactory and achieving a detection limit at the nanomolar level. The living cell image experiments demonstrated the value of sensor 1 in fluorescent visualization of Cd2+ ions in biological systems.

Preparation of a multifunctional material with superhydrophobicity, superparamagnetism, mechanical stability and acids–bases resistance by electrospinning

Co-reporter:Shuai Wang, Qingwen Liu, Yang Zhang, Shaodan Wang, Yaoxian Li, Qingbiao Yang, Yan Song

Applied Surface Science 2013 Volume 279() pp:150-158

Publication Date(Web):15 August 2013

DOI:10.1016/j.apsusc.2013.04.060

Highlights

•: A novel multifunctional material was prepared by electrospinning.
•: Fe₃O₄@SiO₂@POTS nanoparticles were introduced to make the film superparamagnetism.
•: Fe₃O₄@SiO₂@POTS nanoparticles successfully increase the surface roughness.
•: Bead-on-string PVDF affords the role of supporting the whole film as the frame.
•: The film shows stable superhydrophobicity and remarkable mechanical stability.

Colorimetric and fluorescent nanofibrous film as a chemosensor for Hg2+ in aqueous solution prepared by electrospinning and host–guest interaction

Co-reporter:Wei Wang, Yapeng Li, Mingda Sun, Chen Zhou, Yue Zhang, Yaoxian Li and Qingbiao Yang

Chemical Communications 2012 vol. 48(Issue 48) pp:6040-6042

Publication Date(Web):15 Feb 2012

DOI:10.1039/C2CC17664E

A fluorescent sensing film for Hg2+ ions was fabricated by host–guest interaction and electrospinning. When the nanofibrous film was put into a solution of Hg2+ ions, it gave rise to orange fluorescence, causing a clear color change from white to pink-red.

Preparation of quantum dots encoded microspheres by electrospray for the detection of biomolecules

Co-reporter:Lei Sun, Xiaofang Yu, Mingda Sun, Hengguo Wang, Shufei Xu, John D. Dixon, Y. Andrew Wang, Yaoxian Li, Qingbiao Yang, Xiaoyi Xu

Journal of Colloid and Interface Science 2011 Volume 358(Issue 1) pp:73-80

Publication Date(Web):1 June 2011

DOI:10.1016/j.jcis.2011.02.047

In this paper, a novel method based on the electrospray technique has been developed for preparation of quantum dot (QD)-encoded microspheres for the fist time. By electrospraying the mixture of polymer solution and quantum dots solution (single-color QDs or multi-color QDs), it is accessible to obtain a series of composite microspheres containing the functional nanoparticle. Poly(styrene–acrylate) was utilized as the electrospray polymer materials in order to obtain the microsphere modified with carboxyl group on the surface. Moreover, to test the performance of the QD-encoded microsphere in bioapplication, it is carried out that immunofluorescence analysis between antigens of mouse IgG immobilized on the functional microsphere and FITC labeled antibodies of goat–anti-mouse IgG in experiment. To the best of our knowledge, this is the first report of QD-encoded microspheres prepared by electrospray technology. This technology can carry out the one-pot preparation of different color QD-encoded microspheres with multiple intensities. This technology could be also suitable for encapsulating other optical nanocrystals and magnetic nanoparticles for obtaining multifunctional microspheres. All of the results in this paper show that the fluorescence beads made by electrospray technique can be well applied in multiplex analysis. These works provide a good foundation to accelerate application of preparing microspheres by electrospray technique in practice.Graphical abstractQuantum dots encoded microspheres were prepared by electrospray for the fluoroimmunoassays between antigens of the mouse IgG and FITC labeled antibodies of the goat–anti-mouse IgG.Highlights► Polystyrene microspheres with QDs of various colors were prepared by electrospray technology. ► Immunofluorescence analysis was carried out in experiment. ► The technology could be also suitable for encapsulating other optical and magnetic nanoparticles.

Preparation of a durable superhydrophobic membrane by electrospinning poly (vinylidene fluoride) (PVDF) mixed with epoxy–siloxane modified SiO2 nanoparticles: A possible route to superhydrophobic surfaces with low water sliding angle and high water contact angle

Co-reporter:Shuai Wang, Yapeng Li, Xiaoliang Fei, Mingda Sun, Chaoqun Zhang, Yaoxian Li, Qingbiao Yang, Xia Hong

Journal of Colloid and Interface Science 2011 Volume 359(Issue 2) pp:380-388

Publication Date(Web):15 July 2011

DOI:10.1016/j.jcis.2011.04.004

A durable superhydrophobic surface with low water sliding angle (SA) and high water contact angle (CA) was obtained by electrospinning poly (vinylidene fluoride) (PVDF) which was mixed with epoxy–siloxane modified SiO2 nanoparticles. To increase the roughness, modified SiO2 nanoparticles were introduced into PVDF precursor solution. Then in the electrospinning process, nano-sized SiO2 particles irregularly inlayed (it could also be regard as self-assembly) in the surface of the micro-sized PVDF mini-islands so as to form a dual-scale structure. This structure was responsible for the superhydrophobicity and self-cleaning property. In addition, epoxy–siloxane copolymer was used to modify the surface of SiO2 nanoparticles so that the SiO2 nanoparticles could stick to the surface of the micro-sized PVDF mini-islands. Through the underwater immersion test, the SiO2 nanoparticles cannot be separated from PVDF easily so as to achieve the effect of durability. We chiefly explore the surface wettability and the relationship between the mass ratio of modified SiO2 nanoparticles/PVDF and the CA, SA of electrospun mat. As the content of modified SiO2 nanoparticles increased, the value of CA increased, ranging from 145.6° to 161.2°, and the water SA decreased to 2.17°, apparently indicating that the membrane we fabricated has a perfect effect of superhydrophobicity.Graphical abstractA durable superhydrophobic surface, on which epoxy–siloxane modified SiO2 nanoparticles inlayed in the surface of micro-sized PVDF, was successfully prepared by electrospinning. This film exhibited remarkable superhydrophobicity and prominent durability.Highlights► Durable superhydrophobic surfaces with high CA and low SA were fabricated by electrospinning. ► The dual-scale structure made of PVDF mini-islands and modified SiO2 nanoparticles on the surface is responsible for the superhydrophobicity and self-cleaning properties. ► It is important that the SiO2 nanoparticles cannot be apart from PVDF and washed away easily through the underwater immersion because of epoxy–siloxane copolymer which is used to modify the surface of SiO2 nanoparticles test so as to achieve the effect of durability. ► We believe that more superhydrophobic surfaces with various properties desired can be further explored to prepare in the future by mixing various substances modified nanoparticles.

Rhodamine-based highly sensitive colorimetric off-on fluorescent chemosensor for Hg2+ in aqueous solution and for live cell imaging

Co-reporter:Hengguo Wang, Yapeng Li, Shufei Xu, Yanchun Li, Chen Zhou, Xiaoliang Fei, Lei Sun, Chaoqun Zhang, Yaoxian Li, Qingbiao Yang and Xiaoyi Xu

Organic & Biomolecular Chemistry 2011 vol. 9(Issue 8) pp:2850-2855

Publication Date(Web):02 Mar 2011

DOI:10.1039/C0OB01032D

A novel rhodamine-based highly sensitive and selective colorimetric off-on fluorescent chemosensor for Hg2+ ions is designed and prepared by using the well-known thiospirolactam rhodamine chromophore and furfural hydrazone as signal-reporting groups. The photophysical characterization and Hg2+-binding properties of sensor RS1 in neutral N, N-dimethylformamide (DMF) aqueous solution are also investigated. The signal change of the chemosensor is based on a specific metal ion induced reversible ring-opening mechanism of the rhodamine spirolactam. The response of the chemosensor for Hg2+ ions is instantaneous and reversible. And it successfully exhibits a remarkably “turn on” response toward Hg2+ over other metal ions (even those that exist in high concentration). Moreover, this sensor is applied for in vivo imaging in Rat Schwann cells to confirm that RS1 can be used as a fluorescent probe for monitoring Hg2+ in living cells with satisfying results, which further demonstrates its value of practical applications in environmental and biological systems.

A novel two-nozzle electrospinning process for preparing microfiber reinforced pH-sensitive nano-membrane with enhanced mechanical property

Co-reporter:Chaoqun Zhang, Yapeng Li, Wei Wang, Naiqian Zhan, Ning Xiao, Shuai Wang, Yaoxian Li, Qingbiao Yang

European Polymer Journal 2011 Volume 47(Issue 12) pp:2228-2233

Publication Date(Web):December 2011

DOI:10.1016/j.eurpolymj.2011.09.015

A novel pH sensitive membrane (pHS-M) with mechanical integrity is synthesized firstly by two nozzles electrospining in this work. We report an excellent strategy here to combine indicative nanofiber from 9% PAN solution and micro-sized fibers from 20% PA-66 solution homogeneously in one electrospinning setup. The pH indicative property of electrospun sheet can be achieved by PAN nanofibers that first aminating with ethylenediamine and then immobilizing phenolphthalein covalently through a Mannich reaction, while micro-sized PA-66 fibers are responsible for the improvement of mechanical property of electrospun mat due to their elastic and flexible behavior. The composite membrane was characterized by SEM, FTIR and UV–vis spectroscopy. Results show that two kinds of pH sensitive membranes (single PAN nanofibers (pHS-NF) or composite PAN/PA-66 fiber (pHS-CF)) all exhibited remarkable color change from pale yellow to violet in a wide range of alkaline solution and rapid response time within 100 s. But after added of microfiber, the tensile strength was enhanced from 1.3 MPa to 6.90 MPa prominently which is beneficial to put the membrane into practice.A pH sensitive PAN/PA-66 composite membrane with mechanical integrity was synthesized firstly by two nozzles electrospining in this work. This film exhibited remarkable halochromic and prominently mechanical property.

Magnetically separable iron oxide nanostructures-TiO2 nanofibers hierarchical heterostructures: controlled fabrication and photocatalytic activity

Co-reporter:Hengguo Wang, Xiaoliang Fei, Ling Wang, Yapeng Li, Shufei Xu, Mingda Sun, Lei Sun, Chaoqun Zhang, Yaoxian Li, Qingbiao Yang and Yen Wei

New Journal of Chemistry 2011 vol. 35(Issue 9) pp:1795-1802

Publication Date(Web):24 Jun 2011

DOI:10.1039/C1NJ20051H

Novel hierarchical heterostructures of TiO2 nanofibers separately decorated with hematite (α-Fe2O3) or magnetite (Fe3O4) were prepared by combining the electrospinning technique and the hydrothermal method. Extensive characterizations of the resulting hierarchical heterostructures revealed that the secondary α-Fe2O3 or Fe3O4 nanostructures successfully grew on the surface of the primary TiO2 nanofibers substrates, thus integrating the magnetic and photocatalytic properties into the α-Fe2O3/TiO2 and Fe3O4/TiO2 hierarchical heterostructures. The component as well as morphology of the secondary α-Fe2O3 or Fe3O4 nanostructures could be further controlled by simply tuning the experimental parameters. Moreover, the magnetic properties and photocatalytic activities of the hierarchical heterostructures were systematically investigated. Electronic interactions between two semiconductors are the major contributing factor for the changed photoactivity. Most importantly, magnetic measurements showed that the Fe3O4/TiO2 hierarchical heterostructures were ferromagnetic and they could be separated and collected easily using a commercial magnet.

Porphyrin-functionalized Fe3O4@SiO2 core/shell magnetic colorimetric material for detection, adsorption and removal of Hg2+ in aqueous solution

Co-reporter:Lei Sun, Yaoxian Li, Mingda Sun, Hengguo Wang, Shufei Xu, Chaoqun Zhang and Qingbiao Yang

New Journal of Chemistry 2011 vol. 35(Issue 11) pp:2697-2704

Publication Date(Web):26 Sep 2011

DOI:10.1039/C1NJ20307J

A fluorimetric/colorimetric mercury(II) sensor based on porphyrin-functionalized Fe3O4@SiO2 core/shell magnetic microspheres has been developed and demonstrated by sol–gel grafting reaction. These multifunctional microspheres show excellent fluorescence sensitivity and selectivity towards Hg2+ over other metal ions (K+, Na+, Ba2+, Mn2+, Ca2+, Co2+, Cu2+, Ag+, Mn2+, Ni2+ and Pb2+). Upon addition of Hg2+, the color of porphyrin-functionalized Fe3O4@SiO2 microspheres changes from red to green within 1 min and the fluorescence of microspheres becomes obviously weak. Conversely, no significant changes in fluorescence emission or color are observed in the parallel experiment with other metal ions. Regarding the reversibility of the microspheres, the color and fluorescence of the porphyrin-functionalized Fe3O4@SiO2 microspheres in the presence of Hg2+ ion are found to be almost reversible when the microspheres are treated with EDTA solution. Furthermore, the used microspheres can efficiently remove Hg2+ ions in aqueous solution and easily separated from the mixture by adding an external magnetic field. Theses results suggest that functionalized Fe3O4@SiO2 core/shell magnetic microspheres are potentially useful materials for simultaneously detecting and removing environmental pollutants.

Layer-by-Layer Assembled Fe3O4@C@CdTe Core/Shell Microspheres as Separable Luminescent Probe for Sensitive Sensing of Cu2+ Ions

Co-reporter:Hengguo Wang, Lei Sun, Yapeng Li, Xiaoliang Fei, Mingda Sun, Chaoqun Zhang, Yaoxian Li, and Qingbiao Yang

Langmuir 2011 Volume 27(Issue 18) pp:11609-11615

Publication Date(Web):August 3, 2011

DOI:10.1021/la202295b

A novel multifunctional microsphere with a fluorescent CdTe quantum dots (QDs) shell and a magnetic core (Fe3O4) has been successfully developed and prepared by a combination of the hydrothermal method and layer-by-layer (LBL) self-assembly technique. The resulting fluorescent Fe3O4@C@CdTe core/shell microspheres are utilized as a chemosensor for ultrasensitive Cu2+ ion detection. The fluorescence of the obtained chemosensor could be quenched effectively by Cu2+ ions. The quenching mechanism was studied and the results showed the existence of both static and dynamic quenching processes. However, static quenching is the more prominent of the two. The modified Stern–Volmer equation showed a good linear response (R2 = 0.9957) in the range 1–10 μM with a quenching constant (Ksv) of 4.9 × 104 M–1. Most importantly, magnetic measurements showed that the Fe3O4@C@CdTe core/shell microspheres were superparamagnetic and they could be separated and collected easily using a commercial magnet in 10 s. These results obtained not only provide a way to solve the embarrassments in practical sensing applications of QDs, but also enable the fabrication of other multifunctional nanostructure-based hybrid nanomaterials.

Aggregation states of rhodamine 6G in electrospun nanofibrous films

Co-reporter:Hengguo Wang, Qingbiao Yang, Lei Sun, Shuai Wang, Wei Wang, Chaoqun Zhang, Yanchun Li, Shufei Xu, Yaoxian Li

Journal of Colloid and Interface Science 2010 Volume 341(Issue 2) pp:224-231

Publication Date(Web):15 January 2010

DOI:10.1016/j.jcis.2009.09.044

Novel fluorescent composite nanofibrous films of rhodamine 6G (Rh6G) and polyacrylonitrile (PAN) are first prepared by electrospinning. The aggregation states of Rh6G in electruspun nanofibrous films are studied as a function of concentrations and characterized by UV–vis absorption spectroscopy and emission and excitation fluorescence spectroscopy. We have also used casting films as reference material to compare the effect of incorporation of Rh6G in electrospun nanofibrous films and casting films. The large specific surface area of the nanofibers and fast evaporation of the solvents in the electrospinning process reduced the aggregation of Rh6G. The appearance of fluorescent J-type dimers, even at higher dye concentration in elctrospun films, demonstrates that the electrospun films are an ideal material for incorporation of fluorescent dyes.Fluorescent composite nanofibers of the rhodamine 6G and polyacrylonitrile (PAN) are prepared by electrospinning.

A novel multinozzle electrospinning process for preparing superhydrophobic PS films with controllable bead-on-string/microfiber morphology

Co-reporter:Naiqian Zhan, Yaoxian Li, Chaoqun Zhang, Yan Song, Hengguo Wang, Lei Sun, Qingbiao Yang, Xia Hong

Journal of Colloid and Interface Science 2010 Volume 345(Issue 2) pp:491-495

Publication Date(Web):15 May 2010

DOI:10.1016/j.jcis.2010.01.051

Superhydrophobic polystyrene (PS) surfaces with mechanical integrity were manufactured by electrospinning in this work. We first report a novel strategy here to combine bead-on-string fibers from 4% PS solution and micro-sized fibers from 20% PS solution homogeneously in one electrospinning step by multinozzle electrospinning. The superhydrophobicity of electrospun sheet can be achieved by the presence of bead-on-string fibers, while micro-sized PS fibers are responsible for the improvement of mechanical property of electrospun mat due to their elastic and flexible behavior. The distinctive design of our multinozzle electrospinning setup places two nozzles in separate electrical fields which guarantee that fibers with different structures are mixed homogeneously. We investigate the relationship between the mass ratio of fibers from two types of solutions and the CA of electrospun mat, the effect of mass ratio to the mechanical property of electrospun mat can also be observed. The result shows that CA value of PS surface merely comprised of bead-on-string fibers could reach up to 154.65°. As the content of microfibers increased, the value of CA decreased, ranging from 153.66° to 145.94°, but the tensile strength of composite mat was enhanced from 0.50 MPa to 1.22 MPa correspondingly which is beneficial to put the mats into practice.This study demonstrates the fabrication of superhydrophobic polystyrene surfaces containing bead-on-string fibers and micro-sized fibers by multinozzle electrospinning. The relationship between CA value and mass ratio of bead-on-string fibers/micro-sized fibers, as well as the effect of micro-sized fibers to the mechanical property of electrospun mat is investigated.

Synthesis of magnetic and fluorescent multifunctional hollow silica nanocomposites for live cell imaging

Co-reporter:Lei Sun, Yang Zang, Mingda Sun, Hengguo Wang, Xuanjing Zhu, Shufei Xu, Qingbiao Yang, Yaoxian Li, Yaming Shan

Journal of Colloid and Interface Science 2010 Volume 350(Issue 1) pp:90-98

Publication Date(Web):1 October 2010

DOI:10.1016/j.jcis.2010.06.041

In this paper, we report a synthesis of multifunctional core/shell silica nanocomposites in mixed water–ethanol solvents at room temperature. Water-soluble CTAB-stabilized nanoparticles (Fe3O4 and quantum dots) are used as templates and tetraethoxysilane (TEOS) is used as a precursor to fabricate multifunctional hollow silica nanocomposites. Owing to the high abundance of folate receptors in many cancer cells, folic acid is used as the targeting ligand. By coupling with folic acids, the multifunctional silica nanocomposites conjugates are successfully used for tumor cell imaging. In vitro cellular uptakes of such SiO2 nanocomposites are investigated with fluorescence microscope, which demonstrate much higher internalization of the folate-decorated SiO2 nanocomposites by Hela cancer cells which are of over-expression of folate receptors than the cellular uptake by NIH 3T3 fibroblast cells which are of low expression of folate receptors. Magnetic manipulation, fluorescence imaging, hollow structure, and cell targeting are simultaneously possible using a multifunctional silica nanocomposite. Our results demonstrate a robust hydrophobic nanoparticles-based approach for preparing multifunctional and biocompatible hollow silica composites, which could be also suitable for silica coating of other kinds of nanoparticles.Graphical abstractFolate-conjugated magnetic and luminescent hollow silica nanocomposites are prepared for live cells fluorescence imaging.Research highlights► Multifunctional hollow silica spheres in mixed water–ethanol solvents were synthesized. ► Multifunctional hydrophobic nanoscaled particulates were assembled in a single entity. ► Folate-conjugated magnetic and luminescent hollow silica spheres were used for cell imaging.

Synthesis and characterization of multifunctional CdTe/Fe2O3@SiO2 core/shell nanosensors for Hg2+ ions detection

Co-reporter:Hengguo Wang, Yapeng Li, Xiaoliang Fei, Lei Sun, Ligong Zhang, Zhenzhong Zhang, Yue Zhang, Yaoxian Li and Qingbiao Yang

New Journal of Chemistry 2010 vol. 34(Issue 12) pp:2996-3003

Publication Date(Web):01 Oct 2010

DOI:10.1039/C0NJ00393J

Novel multifunctional magnetic-photoluminescent Hg2+ ion sensing nanocomposites were developed by applying SiO2 as the encapsulation agent to package Fe2O3 NRs and CdTe QDs, resulting in CdTe/Fe2O3@SiO2 core/shell nanostructures. The core/shell structural nanocomposites were confirmed by field-emission scanning electron microscopy (FESEM), energy dispersive X-ray analysis (EDXA), X-ray diffraction (XRD) patterns, high-resolution transmission electron microscopy (HRTEM) and selective-area electron diffraction (SAED) patterns. Photoluminescence (PL) spectroscopy and superconducting quantum interference device (SQUID) were used to investigate the optical and magnetic properties of the core/shell structural nanocomposites, respectively. The fluorescence of the obtained nanocomposites could be quenched effectively by Hg2+ ions without obvious changes of spectral widths and optical shift of PL emission. The quenching mechanism was studied and the results showed the existence of both static and dynamic quenching processes. The modified Stern–Volmer equation showed a linear response in the range of 1 to 10 μM with a quenching constant (Ksv) of 3.5 × 104 M−1. This hydrophilic, biocompatible, multifunctional, easy to separate and sensitive fluorescence nanosensor may find applications in Hg2+ ion determination in the biological and environmental areas.

A novel approach to prepare silver chloride nanoparticles grown on the surface of PAN nanofibre via electrospinning combined with gas–solid reaction

Co-reporter:Chaoqun Zhang, Qingwen Liu, Naiqian Zhan, Qingbiao Yang, Yan Song, Lei Sun, Hengguo Wang, Yaoxian Li

Colloids and Surfaces A: Physicochemical and Engineering Aspects 2010 Volume 353(Issue 1) pp:64-68

Publication Date(Web):5 January 2010

DOI:10.1016/j.colsurfa.2009.10.022

Well-defined silver chloride nanoparticles grown on the surface of PAN nanofibre were synthesized by electrospinning technology combined with gas–solid reaction. This method can avoid the possibility of the waste of raw material as well as enhance the usage rate of AgNO3. The PAN nanofibre can be recycled easily. X-ray powder diffraction (XRD) shows the presence of crystal AgCl, X-ray photoelectron spectroscopy (XPS) confirm that there are chemical bonds and interaction between the surface modified PAN nanofibre and Ag ions. This will be propitious to prevent nanoparticles from aggregation. Field-emission scanning electron microscopy (FESEM) and transmission electron microscopy (TEM) gave the direct evidence that AgCl nanoparticles have been dispersed on the surface of PAN nanofibre homogeneously.

Silver nanoparticles grown on the surface of PAN nanofiber: Preparation, characterization and catalytic performance

Co-reporter:Chaoqun Zhang, Qingbiao Yang, Naiqian Zhan, Lei Sun, Hengguo Wang, Yan Song, Yaoxian Li

Colloids and Surfaces A: Physicochemical and Engineering Aspects 2010 Volume 362(1–3) pp:58-64

Publication Date(Web):5 June 2010

DOI:10.1016/j.colsurfa.2010.03.038

A convenient route, based on electrospinning is designed for the preparation of silver/polyacrylonitrile (Ag/PAN) composite nanofiber film. Ag nanoparticles (Ag NPs) with uniform size were well dispersed on the surface of the PAN nanofiber (PANNF) through chelating effect. This method will be propitious to prevent Ag NPs from aggregation which is one of the most important things for defining their catalytic performance. Another advantage is that the prepared composite nanofiber film is extremely easy for catalyst recycling. The catalytic activity of Ag/PAN composite nanofiber film was tracked by ultraviolet–visible (UV–vis) spectroscopy. Fourier transform infrared spectroscopy (FTIR) revealed the functional groups. Field-emission scanning electron microscopy (FESEM) and transmission electron microscopy (TEM) gave direct evidence that Ag NPs have dispersed on the surface of PANNF homogeneously. X-ray powder diffraction (XRD) showed the presence of crystal Ag. X-ray photoelectron spectra (XPS) confirmed that there were chemical bonds and interaction between surface modified PANNF and Ag ions.

Electrospun poly(methyl methacrylate) nanofibers and microparticles

Co-reporter:Hengguo Wang;Qingwen Liu;Yanchun Li

Journal of Materials Science 2010 Volume 45( Issue 4) pp:

Publication Date(Web):2010/02/01

DOI:10.1007/s10853-009-4035-1

Electrospinning at relatively low polymer concentrations results in particles rather than fibers. This particle-formation process can be termed as electrospray. So electrospinning/electrospray is a highly versatile method to process fibers and particles with different morphologies. In this work, poly(methyl methacrylate) (PMMA) micro- and nanostructures with different morphologies (fibers, spheres, cup-like, and ring-like) have been produced by a facile electrospinning/electrospray method. PMMA was electrospun into various morphologies from only DMF without any other solvents. Field emission scanning electron microscope (FESEM) images demonstrate the different morphologies and prove this technique to be an effective method for obtaining morphology-controllable polymer materials by changing the processing parameters. These micro- and nanostructured polymer materials may find applications in drug delivery and filtration media.

Fabrication and characterization of CdTe nanoparticles attached to poly(4-vinylpyridine) nanofibers

Co-reporter:Shugang Wang;Yaoxian Li;Jun Li;Jianshi Du;Jie Bai;Xuesi Chen

Journal of Applied Polymer Science 2008 Volume 108( Issue 1) pp:281-286

Publication Date(Web):

DOI:10.1002/app.27588

Abstract

The major objective of this work was to characterize the status of CdTe nanoparticles attached to the surface of poly(4-vinylpyridine) (P4VP) nanofibers. Scanning electron microscopy and transmission electron microscopy images indicated that the attachment of CdTe nanoparticles enlarged the diameter of P4VP nanofibers. Moreover, the results of the energy-dispersive X-ray spectrum and the electron diffraction pattern revealed that the deposition on the surface of P4VP nanofibers was CdTe in a cubic lattice. Furthermore, CdTe existed in its optical style according to photoluminescence spectra. X-ray photoelectron spectroscopy verified Cd in CdTe nanoparticles combined with the N atom in P4VP nanofibers. Therefore, the obtained results provide some references for preparing coaxial nanofibers attached by other nanoparticles. © 2007 Wiley Periodicals, Inc. J Appl Polym Sci, 2008

Introducing CTAB into CdTe/PVP nanofibers enhances the photoluminescence intensity of CdTe nanoparticles

Co-reporter:Shugang Wang, Yaoxian Li, Yongzhi Wang, Qingbiao Yang, Yen Wei

Materials Letters 2007 Volume 61(Issue 25) pp:4674-4678

Publication Date(Web):October 2007

DOI:10.1016/j.matlet.2007.03.016

The major objective of this work is focused on the preparation and characterization of the photoluminescence (PL) property of poly(vinyl pyrrolidone) (PVP) embedding CdTe nanoparticles. The CdTe nanoparticles were generated via the reaction of Cd2+ with NaHTe and then stabilized by thiolglycolic acid (TGA). In the process of preparing CdTe/PVP nanofibers by electrospinning, a surfactant, cetyltrimethylammonium bromide (CTAB), was introduced to prevent CdTe nanoparticles from congregating inside the PVP nanofibers. Then the results of scanning electron microscopy (SEM), transmission electron microscopy (TEM) and electron diffraction (ED) showed that the average diameter of CdTe/PVP nanofibers was 300 (± 61) nm, in which the CdTe nanoparticles were incorporated into the PVP nanofibers homogeneously. Finally, the PL spectra proved that the photoluminescence intensity of CdTe/PVP nanofibers was enhanced by the addition of CTAB.

A simple and effective route for the preparation of poly(vinylalcohol) (PVA) nanofibers containing gold nanoparticles by electrospinning method

Co-reporter:Jie Bai, Yaoxian Li, Songtao Yang, Jianshi Du, Shugang Wang, Jifu Zheng, Yongzhi Wang, Qingbiao Yang, Xuesi Chen, Xiabin Jing

Solid State Communications 2007 Volume 141(Issue 5) pp:292-295

Publication Date(Web):February 2007

DOI:10.1016/j.ssc.2006.10.024

Poly(vinylalcohol) (PVA) nanofibers containing gold nanoparticles have been simply obtained by electrospinning a solution containing gold nanoparticles without the additional step of introducing other stabilizing agents. The optical property of gold nanoparticles in PVA aqueous solution was observed by UV–visible absorption spectra. Morphology of the Au/PVA nanofibers and distribution of the gold nanoparticles were characterized by transmission electron microscopy (TEM). The structure transformation was characterized from PVA to PVA/Au composite by Fourier transform infrared spectroscopy (FTIR).

A reusable nanofibrous film chemosensor for highly selective and sensitive optical signaling of Cu2+ in aqueous media

Co-reporter:Wei Wang, Xiuling Wang, Qingbiao Yang, Xiaoliang Fei, Mingda Sun and Yan Song

Chemical Communications 2013 - vol. 49(Issue 42) pp:NaN4835-4835

Publication Date(Web):2013/04/08

DOI:10.1039/C3CC41317A

Colorimetric and fluorescent nanofibrous film as a chemosensor for Hg2+ in aqueous solution prepared by electrospinning and host–guest interaction

Co-reporter:Wei Wang, Yapeng Li, Mingda Sun, Chen Zhou, Yue Zhang, Yaoxian Li and Qingbiao Yang

Chemical Communications 2012 - vol. 48(Issue 48) pp:NaN6042-6042

Publication Date(Web):2012/02/15

DOI:10.1039/C2CC17664E

Simple naphthalimide-based fluorescent sensor for highly sensitive and selective detection of Cd2+ and Cu2+ in aqueous solution and living cells

Co-reporter:Wei Wang, Qian Wen, Yue Zhang, Xiaoliang Fei, Yaoxian Li, Qingbiao Yang and Xiaoyi Xu