Benzaldehyde, 2-[2-(4-fluorophenyl)ethynyl]-

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CAS: 1042369-43-6
MF: C15H9OF
MW: 224.22976
Synonyms: Benzaldehyde, 2-[2-(4-fluorophenyl)ethynyl]-

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WeiXing Chang

Nankai Univerisity
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Jing Li

Nankai Univerisity
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Lingyan Liu

Nankai University
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Co-reporter: Junying Wang, Kaimeng Huang, Lingyan Liu, Weixing Chang, Jing Li
pp: 2659-2663
Publication Date(Web):20 May 2015
DOI: 10.1016/j.tetlet.2015.03.105
A facile and highly efficient methodology was developed to synthesize the functional indene acetal through the cyclization of o-(alkynyl)styrene ether catalyzed by the Au(I) in the presence of MeOH. The 2-aryl-1H-indene acetals were obtained in excellent yields and could be easily transformed to indene aldehyde. Notably, the MeOH played a dual role, which includes acting as both a nucleophilic reagent and an auxiliary to mediate the cyclization of the 1,5-enyne ether.A facile and highly efficient methodology was developed to synthesize the functional indene acetal through the cyclization of o-(alkynyl)styrene ether catalyzed by the Au(I) in the presence of MeOH. The 2-aryl-1H-indene acetals were obtained in excellent yields and could be easily transformed to indene aldehyde. Notably, the MeOH played a dual role, which includes acting as both a nucleophilic reagent and an auxiliary to mediate the cyclization of the 1,5-enyne ether.Image for unlabelled figure

Zhi-Wei Miao

Nankai University
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Ruimao Hua

Tsinghua University
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Zhiyong Wang

University of Science and Technology of China
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Ying Cheng

Beijing Normal University
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Jian Hao

Shanghai University
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HaiZhen Jiang

Shanghai University
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Shaozhong Wang

Nanjing University
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