N-Benzylidene-4-methylbenzenesulfonamide

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CAS: 13707-41-0
MF: C14H13NO2S
MW: 259.32352
Synonyms: N-Benzylidene-4-methylbenzenesulfonamide

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Yongfang Li

Institute of Chemistry, Chinese Academy of Sciences
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Li Liu

Institute of Chemistry, Chinese Academy of Sciences
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Co-reporter: Liang Cheng, Li Liu, Chuan Li, Han Jia, Dong Wang, Yong-Jun Chen
pp: 4004-4007
Publication Date(Web):1 August 2012
DOI: 10.1016/j.tetlet.2012.05.119
Indolines bearing different N-protecting groups (N-Tbf and N-Boc) were deprotonated regioselectively at C-2 (sp3 hybridized ortho-H) and C-7 (sp2 hybridized para-H) of the indoline ring, respectively. The generated organolithium intermediates reacted with aldimines to give the desired products in good yields with excellent anti-diastereoselectivities (>99:1). The produced N-Ts-(1-Tbf-indolin-2-yl)methanamine was facilely transformed to a fused heterocyclic compound.Image for unlabelled figure

Jin-Hong Lin

Chinese Academy of Sciences
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Ji-Chang Xiao

Chinese Academy of Sciences
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Gang Zhao

Chinese Academy of Sciences
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Yan Liu

Dalian Institute of Chemical Physics
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WeiXing Chang

Nankai Univerisity
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Jing Li

Nankai Univerisity
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Lingyan Liu

Nankai University
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Jin Qu

Nankai University
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